000			03760nam a22004577a 4500
008			130912s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
022			_a1094-8341
040			_aOvid MEDLINE(R)
099			_a22186255
245			_aHeritability of serum sodium concentration: evidence for sex- and ethnic-specific effects.
251			_aPhysiological Genomics. 44(3):220-8, 2012 Feb 13.
252			_aPhysiol Genomics. 44(3):220-8, 2012 Feb 13.
253			_aPhysiological genomics
260			_c2012
260			_fFY2012
266			_d2013-09-17
520			_aSerum sodium concentration is the clinical index of systemic water balance. Although disordered water balance is common and morbid, little is known about genetic effects on serum sodium concentration at the population level. Prior studies addressed only participants of European descent and either failed to demonstrate significant heritability or showed only modest effect. We investigated heritability of serum sodium concentration in large cohorts reflecting a range of races/ethnicities, including the Framingham Heart Study (FHS, non-Hispanic Caucasian), the Heredity and Phenotype Intervention Heart Study (HAPI, Amish Caucasian), the Jackson Heart Study (JHS, African American), the Strong Heart Family Study (SHFS, American Indian), and the Genetics of Kidney Disease in Zuni Indians Study (GKDZI, American Indian). Serum sodium was transformed for the osmotic effect of glucose, and participants with markedly elevated glucose or reduced estimated glomerular filtration rate (eGFR) were excluded. Using a standard variance components method, incorporating covariates of age, glucose, and eGFR, we found heritability to be high in African American and American Indian populations and much more modest in non-Hispanic Caucasian populations. Estimates among females increased after stratification on sex and were suggestive among female participants in FHS (0.18 +/- 0.12, P = 0.057) and male participants in JHS (0.24 +/- 0.16, P = 0.067) and statistically significant among female participants in JHS (0.44 +/- 0.09, P = 1 x 10 -7), SHFS (0.59 +/- 0.05, P = 9.4 x 10-46), and GKDZI (0.46 +/- 0.15, P = 1.7 x 10-4), and male participants in HAPI (0.18 +/- 0.12, P = 0.03) and SHFS (0.67 +/- 0.07, P = 5.4 x 10-26). Exclusion of diuretic users increased heritability among females and was significant in all cohorts where data were available. In aggregate, these data strongly support the heritability of systemic water balance and underscore sex and ethnicity-specific effects.
546			_aEnglish
650			_a*African Americans/ge [Genetics] _9814
650			_a*Amish/ge [Genetics] _9815
650			_a*European Continental Ancestry Group/ge [Genetics] _9817
650			_a*Indians, North American/ge [Genetics] _9818
650			_a*Quantitative Trait, Heritable _9819
650			_a*Sodium/bl [Blood] _9820
650			_a*Water-Electrolyte Balance/ge [Genetics] _9821
650			_aAge Factors _9712
650			_aAnalysis of Variance _9816
650			_aCohort Studies _9187
650			_aFemale _97
650			_aHumans _911
650			_aMale _914
650			_aSex Factors _9499
651			_aMedStar Health Research Institute
657			_aComparative Study
657			_aJournal Article
657			_aResearch Support, N.I.H., Extramural
700			_aUmans, Jason G _9561
790			_aChang YP, Chen Z, Cohen DM, Cole SA, Comuzzie AG, Flessner MF, Fu Y, Gipson T, Hitzemann R, Maccluer JW, McWeeney S, Shah VO, Shuldiner AR, Taylor HA, Umans JG, Voruganti VS, Wilmot B, Wilson JG, Zager PG
856			_uhttp://dx.doi.org/10.1152/physiolgenomics.00153.2011 _zhttp://dx.doi.org/10.1152/physiolgenomics.00153.2011
942			_cART _2z _dArticle
999			_c1392 _d1392