000			02417nam a22003857a 4500
008			240723s20242024 xxu||||| |||| 00| 0 eng d
022			_a2000-9666
024			_ajchim-14-01-043 [pii]
024			_aPMC10932500 [pmc]
040			_aOvid MEDLINE(R)
099			_a38482078
245			_aTissue Plasminogen Activator in Acute Cardiac Arrest.
251			_aJournal of Community Hospital Internal Medicine Perspectives. 14(1):43-49, 2024.
252			_aJ Community Hosp Intern Med Perspect. 14(1):43-49, 2024.
253			_aJournal of community hospital internal medicine perspectives
260			_c2024
260			_p2024
260			_fFY2024
265			_sepublish
265			_tPubMed-not-MEDLINE
520			_aTissue plasminogen activator (TPA) is indicated as an empiric therapy for refractory out-of-the-hospital cardiac arrest for suspected pulmonary embolism and myocardial infarction. Intracranial hemorrhage following TPA administration is a rare complication resulting in increased morbidity and mortality. A history of intracranial bleed, oral anticoagulant use prior to hospital admission, low body weight, and unstable hypertension with blood pressure above 180/110 mmHg at the time of presentation are associated with intracranial bleeding following tPA administration. Dedicated imaging including a Computed Tomography of the head without contrast, while feasible for patients presenting with acute stroke, is impractical in the setting of cardiac arrest. Here we report a case of 66 years old patient who presented in context of refractory cardiac arrest with recurrent PEAs with interval return of spontaneous circulation (ROSC) and was given tPA with eventual ROSC. He was subsequently found to have both a subarachnoid and intraventricular hemorrhage. Copyright © 2024 Greater Baltimore Medical Center.
546			_aEnglish
650			_zAutomated
651			_aMedStar Franklin Square Medical Center
651			_aMedStar Union Memorial Hospital
656			_aHospitalist
656			_aInternal Medicine Residency
657			_aCase Reports
700			_aAcharya, Indira _bMUMH _cInternal Medicine Residency _dMBBS
700			_aDeBoer, Scott R _bMFSMC
700			_aHaas, Christopher _bMUMH
790			_aAcharya I, DeBoer SR, Haas CJ
856			_uhttps://dx.doi.org/10.55729/2000-9666.1295 _zhttps://dx.doi.org/10.55729/2000-9666.1295
942			_cART _dArticle
999			_c14276 _d14276