000			03059nam a22004097a 4500
008			240807s20242024 xxu||||| |||| 00| 0 eng d
022			_a2192-5682
040			_aOvid MEDLINE(R)
099			_a38721941
245			_aSickle Cell Disease Has No Impact on 10-Year Cumulative Incidence and Indications for Revision Lumbar Fusion.
251			_aGlobal Spine Journal. :21925682241253154, 2024 May 09
252			_aGlobal spine j.. :21925682241253154, 2024 May 09
253			_aGlobal spine journal
260			_c2024
260			_fFY2024
260			_p2024 May 09
265			_saheadofprint
265			_tPublisher
266			_d2024-08-07
266			_z2024/05/09 07:22
520			_aCONCLUSIONS: This study indicates that SCD patients do not have increased risk for revision LF, nor any of its indications.
520			_aMETHODS: A national database was queried to identify patients with and without SCD who underwent primary LF. SCD patients undergoing LF were propensity-score matched in a 1:4 ratio by age, gender, and Charlson Comorbidity Index (CCI) to a matched LF control. In total, 246 SCD patients were included along with 981 and 100,000 individuals in the matched and unmatched control cohorts, respectively. Kaplan-Meier survival analysis was utilized to determine the 10-year cumulative incidence rates of revision LF. Furthermore, multivariable analysis using Cox proportional hazard modeling was performed to compare indications for revisions and surgical complications between cohorts including hardware removal, drainage and evacuation, pseudoarthrosis, and mechanical failure.
520			_aOBJECTIVES: Patients with sickle cell disease (SCD) experience distinct physiological challenges that may alter surgical outcomes. There has been no research establishing 10-year lumbar fusion (LF) implant survivorship rates among individuals with SCD. This study aims to determine the 10-year cumulative incidence and indications for revision LF between patients with and without SCD.
520			_aRESULTS: No significant differences were found in the cumulative incidence of 10-year all-cause revision LF between patients in the SCD cohort and either of the control cohorts (P > .05 for each). Additionally, there were no significant differences between the SCD cohort and either of the control cohorts in regards to the indications for revision or surgical complications in LF (P > .05 for each).
520			_aSTUDY DESIGN: Retrospective Cohort Study.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
650			_zAutomated
651			_aMedStar Washington Hospital Center
656			_aOrthopedics
657			_aJournal Article
700			_aMesfin, Addisu _bMWHC
790			_aSeibold BT, Ramesh A, Parel PM, Quan T, Ranson RA, Mesfin A, Patel TC
856			_uhttps://dx.doi.org/10.1177/21925682241253154 _zhttps://dx.doi.org/10.1177/21925682241253154
858			_yMesfin, Addisu _uhttps://orcid.org/0000-0003-0076-4185 _zhttps://orcid.org/0000-0003-0076-4185
942			_cART _dArticle
999			_c14439 _d14439