000 02687nam a22003977a 4500
008 240807s20242024 xxu||||| |||| 00| 0 eng d
022 _a2694-1902
024 _aCASE23659 [pii]
040 _aOvid MEDLINE(R)
099 _a38976913
245 _aSpinal extramedullary hematopoiesis mimicking an epidural tumor in a patient with high-risk polycythemia vera: illustrative case.
251 _aJournal of Neurosurgery Case Lessons. 8(2), 2024 Jul 08.
252 _aJ. neurosurg., Case lessons. 8(2), 2024 Jul 08.
253 _aJournal of neurosurgery. Case lessons
260 _c2024
260 _fFY2025
260 _p2024 Jul 08
265 _sepublish
265 _tPubMed-not-MEDLINE
266 _d2024-08-07
266 _z2024/07/08 17:52
520 _aBACKGROUND: Here the authors present the case of a 43-year-old male with a history of T-cell lymphoma, which was treated with azacitidine plus cyclophosphamide, doxorubicin, vincristine, and prednisone and autologous hematopoietic cell transplant, and high-risk polycythemia vera (PCV) presenting with severe lower-back pain radiating to the bilateral legs with associated lower-extremity weakness and splenomegaly.
520 _aLESSONS: EMH associated with PCV or myeloproliferative conditions occurring within the spine is a rare phenomenon without a standard treatment approach. https://thejns.org/doi/10.3171/CASE23659.
520 _aOBSERVATIONS: T2-weighted magnetic resonance imaging revealed multilevel epidural lesions involving T1-10 and S1-2. Because of severe spinal canal stenosis, the patient underwent surgical decompression of T5-7, with immediate postoperative alleviation of the lower-extremity pain and complete resolution of the lower-leg weakness. Biopsy results revealed extramedullary hematopoiesis (EMH) mimicking a spinal epidural tumor. EMH is radiosensitive and displays a rapid response to low dosages, so the patient was further treated with palliative radiation therapy for residual tumors and symptom alleviation, as well as hydroxyurea and corticosteroids as indicated for cytoreduction.
546 _aEnglish
650 _zAutomated
656 _aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656 _aNeurosurgery Residency
656 _aRadiation Oncology Residency
657 _aJournal Article
700 _aBhatnagar, Akrita
_bMGUH
_cRadiation Oncology Residency
_dMD
700 _aBreton, Jeffrey
_bMGUH
_cNeurosurgery Residency
_dMD
790 _aHawkins AN, Breton JM, Bhatnagar A, Paudel N, Voyadzis JM
856 _uhttps://dx.doi.org/10.3171/CASE23659
_zhttps://dx.doi.org/10.3171/CASE23659
942 _cART
_dArticle
999 _c14459
_d14459