000			03949nam a22004217a 4500
008			240807s20242024 xxu||||| |||| 00| 0 eng d
022			_a2473-974X
024			_aOTO2150 [pii]
024			_aPMC11165679 [pmc]
040			_aOvid MEDLINE(R)
099			_a38863487
245			_aAssociations Between Race and Survival Outcomes Among Veterans With Head and Neck Cancer in a Racially Diverse Setting.
251			_aOTO Open : The Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation. 8(2):e150, 2024 Apr-Jun.
252			_aOTO Open. 8(2):e150, 2024 Apr-Jun.
253			_aOTO open
260			_c2024
260			_fFY2024
260			_p2024 Apr-Jun
265			_sepublish
265			_tPubMed-not-MEDLINE
266			_d2024-08-07
266			_z2024/06/12 04:04
520			_aDiscussion: Black race appears to be an independent predictor of 3-year OS in veterans with HNSCC. Further studies are warranted to determine the factors responsible for disparities in survival.
520			_aImplications for Practice: This study evaluated the ways in which race affects survival for US veterans with head and neck cancer. The authors found that black veterans had an increased risk of death compared to white patients, and also experienced delays when receiving treatment.
520			_aLevel of Evidence: Level IV. Copyright © 2024 The Authors. OTO Open published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology-Head and Neck Surgery Foundation.
520			_aMethods: Demographic and clinical data were collected on veterans with HNSCC treated with curative intent at our institution between 1999 and 2021. The primary outcome was 3-year OS. Secondary outcomes included treatment delay intervals, including time to treatment initiation (TTI), total package time, and duration of chemoradiation (DCRT).
520			_aObjective: There is limited data on the impact of clinical-demographic factors on survival outcomes among veterans with head and neck squamous cell carcinoma (HNSCC). This study was undertaken to evaluate the impact of race and other factors on overall survival (OS) in a population of veterans with HNSCC treated with curative intent.
520			_aResults: Of 260 veterans with HNSCC, black veterans had significantly lower 3-year OS (49.4%) compared to white veterans (65%, P = .019). Black veterans were also more likely to experience delays in treatment initiation (median TTI 46 vs 41 days; P = .047). Black patients were more likely to receive radiation alone (25.8% [black] vs 8.4% [white]; P < .001) and less likely to receive adjuvant therapy if treated surgically (11.1% [black] vs 22.4% [white]; P = .004), despite any statistically significant difference in stage of their tumor at presentation (Stage I: 21.2% [black] vs 19.6% [white]; P = .372); (Stage IV: 44.4% [black] vs 48.6% [white]; P = .487). Other factors associated with worse 3-year OS included older age (P = .023), lower body mass index (P = .026), neurocognitive disorder/dementia (P = .037), mental health disorders (P = .020), hypopharyngeal primary (P = .001), higher stage disease (P = .002), treatment type (P = .001), need for prophylactic gastrostomy tube (P = .048) or tracheotomy (P = .005), recurrent disease (P = .036), persistent disease (P < .001), distant metastases (P = .002), longer TTI (P = .0362), and longer DCRT (P = .004).
546			_aEnglish
650			_zAutomated
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656			_aOtolaryngology Residency
657			_aJournal Article
700			_aWalsh, Amanda _bMGUH _cOtolaryngology Residency _dMD
790			_aWalsh AR, Giurintano JP, Maxwell JH, Shah AH, Haupt TL, Wadley AE, Kowkuntla SR, Habib AM, Shah V
856			_uhttps://dx.doi.org/10.1002/oto2.150 _zhttps://dx.doi.org/10.1002/oto2.150
942			_cART _dArticle
999			_c14484 _d14484