000			04221nam a22005897a 4500
008			170615s20162016 xxu||||| |||| 00| 0 eng d
022			_a0029-7844
040			_aOvid MEDLINE(R)
099			_a27275800
245			_aObstetric and Neonatal Risks Among Obese Women Without Chronic Disease.
251			_aObstetrics & Gynecology. 128(1):104-12, 2016 Jul
252			_aObstet Gynecol. 128(1):104-12, 2016 Jul
253			_aObstetrics and gynecology
260			_c2016
260			_fFY2017
266			_d2017-06-15
501			_aAvailable online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520			_aCONCLUSION: Prepregnancy obesity is associated with increased risks of a wide range of adverse pregnancy and neonatal outcomes among women without chronic diseases.
520			_aMETHODS: Singleton deliveries (N=112,309) among mothers without chronic diseases in the Consortium on Safe Labor, a retrospective U.S. cohort, were analyzed using Poisson regression with robust variance estimation. Relative risks and 95% confidence intervals (CIs) estimated perinatal risks in relation to prepregnancy obesity status adjusted for age, race-ethnicity, parity, insurance, smoking and alcohol use during pregnancy, and study site.
520			_aOBJECTIVE: To investigate whether prepregnancy obesity is associated with adverse pregnancy outcomes among women without chronic disease.
520			_aRESULTS: Obstetric risks were variably (and mostly marginally) increased as body mass index (BMI) category and obesity class increased. In particular, the risk of gestational hypertensive disorders, gestational diabetes, cesarean delivery, and induction increased in a dose-response fashion. For example, the percentage of gestational diabetes among obese class III women was 14.6% in contrast to 2.8% among women with normal BMIs (corresponding relative risks [95% CI] 1.99 [1.86-2.13], 2.94 [2.73-3.18], 3.97 [3.61-4.36], and 5.47 [4.96-6.04] for overweight, obese class I, obese class II, and obese class III women, respectively) compared with women with normal BMIs. Similarly, neonatal risks increased in a dose-response fashion with maternal BMI status including preterm birth at less than 32 weeks of gestation, large for gestational age (LGA), transient tachypnea, sepsis, and intensive care unit admission. The percentage of LGA neonates increased from 7.9% among women with normal BMIs to 17.3% among obese class III women and relative risks increased to 1.52 (1.45-1.58), 1.74 (1.65-1.83), 1.93 (1.79-2.07), and 2.32 (2.14-2.52) as BMI category increased.
546			_aEnglish
650			_a*Cesarean Section/sn [Statistics & Numerical Data]
650			_a*Diabetes, Gestational/ep [Epidemiology]
650			_a*Fetal Macrosomia/ep [Epidemiology]
650			_a*Hypertension, Pregnancy-Induced/ep [Epidemiology]
650			_a*Obesity
650			_a*Pregnancy Complications/di [Diagnosis]
650			_a*Premature Birth/ep [Epidemiology]
650			_aAdult
650			_aBody Mass Index
650			_aFemale
650			_aHumans
650			_aInfant, Newborn
650			_aObesity/co [Complications]
650			_aObesity/di [Diagnosis]
650			_aObesity/ep [Epidemiology]
650			_aPregnancy
650			_aPregnancy Complications/ep [Epidemiology]
650			_aPregnancy Outcome/ep [Epidemiology]
650			_aRetrospective Studies
650			_aRisk Assessment
650			_aRisk Factors
650			_aUnited States/ep [Epidemiology]
651			_aMedStar Washington Hospital Center
656			_aObstetrics and Gynecology/Maternal-Fetal MedicineIN - Kim, Sung Soo. Epidemiology Branch and the Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland.
657			_aJournal Article
700			_aGrantz, Katherine L
790			_aChen Z, Epps NM, Grantz KL, Hinkle SN, Kim SS, Mendola P, Smarr MM, Wallace ME, Zhu Y
856			_uhttps://dx.doi.org/10.1097/AOG.0000000000001465 _zhttps://dx.doi.org/10.1097/AOG.0000000000001465
942			_cART _dArticle
999			_c2419 _d2419