000			03294nam a22004817a 4500
008			170718s20172017 xxu||||| |||| 00| 0 eng d
022			_a0024-4201
040			_aOvid MEDLINE(R)
099			_a28689316
245			_aHigher Lipophilic Index Indicates Higher Risk of Coronary Heart Disease in Postmenopausal Women.
251			_aLipids. 52(8):687-702, 2017 Aug
252			_aLipids. 52(8):687-702, 2017 Aug
253			_aLipids
260			_c2017
260			_fFY2018
266			_d2017-07-18
520			_aFatty acids (FAs) are essential components of cell membranes and play an integral role in membrane fluidity. The lipophilic index [LI, defined as the sum of the products between FA levels and melting points (degreeC), divided by the total amount of FA: [Formula: see text]] is thought to reflect membrane and lipoprotein fluidity and may be associated with the risk of coronary heart disease (CHD). Therefore, we examined the associations of dietary and plasma phospholipid (PL) LI with CHD risk among postmenopausal women. We determined dietary LI for the cohort with completed baseline food frequency questionnaires and free of prevalent cardiovascular diseases in the Women's Health Initiative (WHI) observational study (N = 85,563). We additionally determined plasma PL LI in a matched case-control study (N = 2428) nested within the WHI observational cohort study. Cox proportional hazard regression and multivariable conditional logistic regression were used to calculate HRs/ORs for CHD risk between quartiles of LI after adjusting for potential sources of confounding and selection bias. Higher dietary LI in the cohort study and plasma PL LI in the case-control study were significantly associated with increased risk of CHD: HR = 1.18 (95% CI 1.07-1.31, P for trend <0.01) and OR = 1.76 (95% CI 1.33-2.33, P for trend <0.01) comparing extreme quartiles and adjusting for potential confounders. These associations still persisted after adjusting for the polyunsaturated to saturated fat ratio. Our study indicated that higher LI based on either dietary or plasma measurements, representing higher FA lipophilicity, was associated with elevated risk of CHD among postmenopausal women.
546			_aEnglish
650			_a*Coronary Disease/ep [Epidemiology]
650			_a*Dietary Fats/ae [Adverse Effects]
650			_a*Fatty Acids/bl [Blood]
650			_a*Postmenopause/bl [Blood]
650			_aAged
650			_aCase-Control Studies
650			_aCell Membrane/me [Metabolism]
650			_aCohort Studies
650			_aCoronary Disease/bl [Blood]
650			_aCoronary Disease/et [Etiology]
650			_aFemale
650			_aHumans
650			_aMiddle Aged
650			_aNutrition Surveys
650			_aProportional Hazards Models
650			_aRisk Factors
651			_aMedStar Health Research Institute
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aHoward, Barbara V
700			_aValdiviezo, Carolina
790			_aAllison MA, Eaton CB, Howard BV, Howe CJ, Lichtenstein AH, Liu Q, Liu S, Manson JE, Martin LW, Matthan NR, Valdiviezo C
856			_uhttps://dx.doi.org/10.1007/s11745-017-4276-8 _zhttps://dx.doi.org/10.1007/s11745-017-4276-8
942			_cART _dArticle
999			_c3342 _d3342