000			02510nam a22004097a 4500
003			OSt
005			20230312215707.0
008			180220s20182018 xxu||||| |||| 00| 0 eng d
022			_a1932-6203
024			_a10.1371/journal.pone.0192106 [doi]
024			_aPONE-D-17-36709 [pii]
040			_aOvid MEDLINE(R) _cwhc
099			_a29432428
245			_aPLAC1 as a serum biomarker for breast cancer.
260			_c2018
266			_d2018-02-20
501			_aAvailable online through MWHC library: 2006 - present
520			_aPlacental-specific protein 1 (PLAC1) is an X-linked trophoblast gene that is re-expressed in several malignancies, including breast cancer, and is therefore a potential biomarker to follow disease onset and progression. Sera from 117 preoperative/pretreatment breast cancer patients and 51 control subjects, including those with fibrocystic disease, were analyzed for the presence of PLAC1 protein as well as its expression by IHC in tumor biopsies in a subset of subjects. Serum PLAC1 levels exceeded the mean plus one standard deviation (mean+SD) of the level in control subjects in 67% of subjects with ductal carcinoma in situ (DCIS), 67% with HER2+ tumors, 73% with triple-negative cancer and 73% with ER+/PR+ tumors. Greater sensitivity was achieved using the mean+2 SD of control PLAC1 serum values, where the false positive rate was 3% and was exceeded by 38%, 40%, 60% and 43% of subjects with DCIS, HER2+, TNBC and ER+/PR+/HER2- tumors. PLAC1 was detected in 97% of tumor biopsies, but did not correlate quantitatively with serum levels. There was no significant correlation of serum PLAC1 levels with race, age at diagnosis, body mass index (BMI) or the presence of metastatic disease. It remains to be determined whether PLAC1 serum levels can serve as a diagnostic biomarker for the presence or recurrence of disease post-surgery and/or therapy.
546			_aEnglish
650			_a*Breast Neoplasms/bl [Blood] _918
650			_a*Pregnancy Proteins/bl [Blood] _923
650			_aAdult _915
650			_aAged, 80 and over _917
650			_aAged _916
650			_aCase-Control Studies _919
650			_aFemale _920
650			_aHumans _921
650			_aMiddle Aged _922
650			_aYoung Adult _924
651			_aWashington Cancer Institute _925
657			_aJournal Article
700			_aBoisvert, Marc _913
700			_aChen, Vincent _912
700			_aGlazer, Robert I _914
700			_aYuan, Hongyan _911
942			_cART _2ddc _dArticle
999			_c3356 _d3356