000			03676nam a22004817a 4500
008			180619s20182018 xxu||||| |||| 00| 0 eng d
022			_a0269-7491
024			_a10.1016/j.envpol.2018.04.129 [doi]
024			_aS0269-7491(17)34188-X [pii]
040			_aOvid MEDLINE(R)
099			_a29793197
245			_aAssociation of low-moderate urine arsenic and QT interval: Cross-sectional and longitudinal evidence from the Strong Heart Study.
251			_aEnvironmental Pollution. 240:894-902, 2018 Sep.
252			_aEnviron Pollut. 240:894-902, 2018 Sep.
253			_aEnvironmental pollution (Barking, Essex : 1987)
260			_c2018
260			_fFY2019
266			_d2018-06-19
269			_fFY2018
520			_aCopyright (c) 2018 Elsevier Ltd. All rights reserved.
520			_aEpidemiologic studies suggest that chronic exposure to arsenic is related to cardiovascular disease (CVD), but the pathophysiological link remains uncertain. We evaluated the association of chronic low-moderate arsenic exposure and arsenic metabolism with baseline difference and annual change in ECG measures (QT interval, JT interval, PR interval, QRS duration, and QT dispersion) using linear mixed models in the Strong Heart Study main cohort (N=1174, median age 55 years) and family study (N=1695 diabetes-free, median age 36 years). At baseline, arsenic exposure was measured as the sum of inorganic and methylated species in urine (SIGMAAs) and arsenic metabolism was measured as the relative percentage of arsenic species. Median SIGMAAs and Bazett heart rate-corrected QT interval (QTc) were 8.6mug/g creatinine and 424ms in the main cohort and 4.3mug/g and 414ms in the family study, respectively. In the main cohort, a comparison of the highest to lowest SIGMAAs quartile (>14.4 vs. <5.2mug/g creatinine) was associated with a 5.3 (95% CI: 1.2, 9.5) ms higher mean baseline QTc interval but no difference in annual change in QTc interval. In the family study, a comparison of the highest to lowest quartile (>7.1 vs. <2.9mug/g creatinine) was associated with a 3.2 (95% CI: 0.6, 5.7) ms higher baseline QTc interval and a 0.6 (95% CI: 0.04, 1.2) ms larger annual increase in QTc interval. Associations with JTc interval were similar but stronger in magnitude compared to QTc interval. Arsenic exposure was largely not associated with PR interval, QRS duration or QT dispersion. Similar to arsenic exposure, a pattern of lower %MMA and higher %DMA was associated with longer baseline QTc interval in both cohorts and with a larger annual change in QTc interval in the family study. Chronic low-moderate arsenic exposure and arsenic metabolism were associated with prolonged ventricular repolarization.
546			_aEnglish
650			_a*Arsenic/ur [Urine]
650			_a*Environmental Exposure/sn [Statistics & Numerical Data]
650			_a*Environmental Pollutants/ur [Urine]
650			_a*Heart Rate/ph [Physiology]
650			_aCardiovascular Diseases/ep [Epidemiology]
650			_aCohort Studies
650			_aCross-Sectional Studies
650			_aDiabetes Mellitus/ep [Epidemiology]
650			_aElectrocardiography
650			_aFemale
650			_aHumans
650			_aMale
650			_aMiddle Aged
651			_aMedStar Health Research Institute
657			_aJournal Article
700			_aHoward, Barbara V
700			_aUmans, Jason G
790			_aBest LG, Devereux RB, Francesconi KA, Goessler W, Guallar E, Howard BV, Moon KA, Navas-Acien A, Okin PM, Umans JG, Zhang Y
856			_uhttps://dx.doi.org/10.1016/j.envpol.2018.04.129 _zhttps://dx.doi.org/10.1016/j.envpol.2018.04.129
942			_cART _dArticle
999			_c3363 _d3363