000			04058nam a22005657a 4500
008			221018s20222022 xxu||||| |||| 00| 0 eng d
022			_a0013-9351
024			_a10.1016/j.envres.2022.114121 [doi]
024			_aS0013-9351(22)01448-7 [pii]
040			_aOvid MEDLINE(R)
099			_a36029836
245			_aCross-sectional analysis of the association between personal exposure to household air pollution and blood pressure in adult women: Evidence from the multi-country Household Air Pollution Intervention Network (HAPIN) trial.
251			_aEnvironmental Research. 214(Pt 4):114121, 2022 Nov.
252			_aEnviron Res. 214(Pt 4):114121, 2022 Nov.
253			_aEnvironmental research
260			_c2022
260			_fFY2023
260			_p2022 Nov
265			_sppublish
265			_tMEDLINE
266			_d2022-10-20
520			_aElevated blood pressure (BP) is a leading risk factor for the global burden of disease. Household air pollution (HAP), resulting from the burning of biomass fuels, may be an important cause of elevated BP in resource-poor communities. We examined the exposure-response relationship of personal exposures to HAP -fine particulate matter (PM2.5), carbon monoxide (CO), and black carbon (BC) - with BP measures in women aged 40-79 years across four resource-poor settings in Guatemala, Peru, India and Rwanda. BP was obtained within a day of 24-h personal exposure measurements at baseline, when participants were using biomass for cooking. We used generalized additive models to characterize the shape of the association between BP and HAP, accounting for the interaction of personal exposures and age and adjusting for a priori identified confounders. A total of 418 women (mean age 52.2 +/- 7.9 years) were included in this analysis. The interquartile range of exposures to PM2.5 was 42.9-139.5 mug/m3, BC was 6.4-16.1 mug/m3, and CO was 0.5-2.9 ppm. Both SBP and PP were positively associated with PM2.5 exposure in older aged women, achieving statistical significance around 60 years of age. The exact threshold varied by BP measure and PM2.5 exposures being compared. For example, SBP of women aged 65 years was on average 10.8 mm Hg (95% CI 1.0-20.6) higher at 232 mug/m3 of PM2.5 exposure (90th percentile) when compared to that of women of the same age with personal exposures of 10 mug/m3. PP in women aged 65 years was higher for exposures >=90 mug/m3, with mean differences of 6.1 mm Hg (95% CI 1.8-10.5) and 9.2 mm Hg (95% CI 3.3-15.1) at 139 (75th percentile) and 232 mug/m3 (90th percentile) respectively, when compared to that of women of the same age with PM2.5 exposures of 10 mug/m3. Our findings suggest that reducing HAP exposures may help to reduce BP, particularly among older women. Copyright © 2022. Published by Elsevier Inc.
546			_aEnglish
650			_a*Air Pollution, Indoor
650			_a*Environmental Exposure
650			_a*Hypertension
650			_aAdult
650			_aAged
650			_aAir Pollution, Indoor/ae [Adverse Effects]
650			_aAir Pollution, Indoor/an [Analysis]
650			_aBlood Pressure
650			_aCooking
650			_aCross-Sectional Studies
650			_aEnvironmental Exposure/ae [Adverse Effects]
650			_aEnvironmental Exposure/an [Analysis]
650			_aFemale
650			_aHumans
650			_aHypertension/ep [Epidemiology]
650			_aMiddle Aged
650			_aParticulate Matter/an [Analysis]
650			_aSoot
651			_aMedStar Health Research Institute
657			_aClinical Trial
657			_aJournal Article
657			_aMulticenter Study
700			_aSimkovich, Suzanne
790			_aCheckley W, Clark M, Davila-Roman V, Diaz A, Fuentes LL, HAPIN Investigators, Hossen S, Jabbarzadeh S, McCracken JP, Nicolaou L, Peel JL, Pillarisetti A, Quinn AK, Rosa G, Simkovich S, Steenland K, Thangavel G, Underhill L, Waller LA
856			_uhttps://dx.doi.org/10.1016/j.envres.2022.114121 _zhttps://dx.doi.org/10.1016/j.envres.2022.114121
942			_cART _dArticle
999			_c339 _d339