000			04991nam a22007937a 4500
008			180928s20192019 xxu||||| |||| 00| 0 eng d
022			_a1876-7591
024			_a10.1016/j.jcmg.2018.07.014 [doi]
024			_aS1936-878X(18)30667-3 [pii]
040			_aOvid MEDLINE(R)
099			_a30219407
245			_aPulmonary Venous Waveforms Predict Rehospitalization and Mortality After Percutaneous Mitral Valve Repair.
251			_aJacc: Cardiovascular Imaging. 12(10):1905-1913, 2019 10.
252			_aJACC Cardiovasc Imaging. 12(10):1905-1913, 2019 10.
252			_zJACC Cardiovasc Imaging. 2018 Sep 06
253			_aJACC. Cardiovascular imaging
260			_c2019
260			_fFY2020
265			_saheadofprint
265			_sppublish
266			_d2018-09-28
268			_aJacc: Cardiovascular Imaging. 2018 Sep 06
269			_fFY2019
520			_aBACKGROUND: The effects of hemodynamic changes during percutaneous mitral valve repair (PMVR) with MitraClip (Abbott Vascular, Santa Clara, California) are incompletely characterized.
520			_aCONCLUSIONS: PV waveforms are important markers of procedural success after PMVR. Our data show intraprocedural PV waveforms may predict rehospitalization and mortality after PMVR. A larger, multicenter cohort will be important to clarify this relationship.
520			_aCopyright (c) 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
520			_aMETHODS: The authors retrospectively reviewed records and intraprocedural transesophageal echocardiograms of 115 consecutive patients (age 76 +/- 12 years) who underwent PMVR for mitral regurgitation (MR) from May 2013 to January 2017 at Emory University Hospital. They assessed intraprocedural PV waveforms for improvement in morphology, measured change in MR grade by semiquantitative methods, evaluated invasive changes in left atrial pressure (LAP) and V-wave, and compared with 30-day and 1-year rehospitalization and all-cause mortality.
520			_aOBJECTIVES: In this study, the authors hypothesized that intraprocedural improvement of pulmonary venous (PV) waveforms are predictive of improved outcomes. In this report, they analyzed intraprocedural invasive and echocardiographic changes with respect to rehospitalization and mortality.
520			_aRESULTS: Ninety-three cases (80%) had PV waveforms before and after clip placement sufficient for analysis, of which 67 (73%) demonstrated intraprocedural improvement in PV morphology and 25 (27%) did not. At 24 months, 57 (85%) of those with PV improvement were living, compared with only 10 (40%) of those without improvement. Proportional hazards models demonstrated a significant survival advantage in those with PV improvement (hazard ratio [HR] = 0.28, 95% confidence interval [CI] 0.08 to 0.93, p = 0.038). By multivariable analysis, PV improvement predicted reduced 1-year cardiac rehospitalization (odds ratio [OR] = 0.18, p = 0.044). Intraprocedural assessment of MR grade and invasive hemodynamics did not consistently predict mortality and rehospitalization.
546			_aEnglish
650			_a*Cardiac Catheterization/mo [Mortality]
650			_a*Echocardiography, Doppler
650			_a*Echocardiography, Transesophageal
650			_a*Heart Valve Prosthesis Implantation/mo [Mortality]
650			_a*Mitral Valve Insufficiency/su [Surgery]
650			_a*Mitral Valve/su [Surgery]
650			_a*Patient Readmission
650			_a*Pulmonary Veins/dg [Diagnostic Imaging]
650			_aAged
650			_aAged, 80 and over
650			_aAtrial Function, Left
650			_aAtrial Pressure
650			_aCardiac Catheterization/ae [Adverse Effects]
650			_aCause of Death
650			_aFemale
650			_aHeart Valve Prosthesis Implantation/ae [Adverse Effects]
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aMitral Valve Insufficiency/dg [Diagnostic Imaging]
650			_aMitral Valve Insufficiency/mo [Mortality]
650			_aMitral Valve Insufficiency/pp [Physiopathology]
650			_aMitral Valve/dg [Diagnostic Imaging]
650			_aMitral Valve/pp [Physiopathology]
650			_aPredictive Value of Tests
650			_aPulmonary Circulation
650			_aPulmonary Veins/pp [Physiopathology]
650			_aRetrospective Studies
650			_aRisk Assessment
650			_aRisk Factors
650			_aTime Factors
650			_aTreatment Outcome
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aThourani, Vinod H
790			_aAlvarez L, Babaliaros VC, Binongo JN, Block PC, Chen JH, Clements SD, Condado JF, Corrigan FE 3rd, Gleason PT, Howell S, Kamioka N, Keegan P, Lerakis S, Lisko JC, Maini A, Reginauld S, Thourani VH, Wei JW
856			_uhttps://dx.doi.org/10.1016/j.jcmg.2018.07.014 _zhttps://dx.doi.org/10.1016/j.jcmg.2018.07.014
942			_cART _dArticle
999			_c3721 _d3721