000			03164nam a22004697a 4500
008			190314s20192019 xxu||||| |||| 00| 0 eng d
022			_a1058-2916
024			_a10.1097/MAT.0000000000000787 [doi]
024			_aNIHMS985753 [mid]
024			_aPMC6221999 [pmc]
040			_aOvid MEDLINE(R)
099			_a29608492
245			_aImpact of Cardiac Resynchronization Therapy on Left Ventricular Unloading in Patients with Implanted Left Ventricular Assist Devices.
251			_aASAIO Journal. 65(2):117-122, 2019 02.
252			_aASAIO J. 65(2):117-122, 2019 02.
252			_zASAIO J. 65(2):117-122, 2019 Feb.
253			_aASAIO journal (American Society for Artificial Internal Organs : 1992)
260			_c2019
260			_fFY2019
265			_sppublish
266			_d2019-03-14
268			_aASAIO Journal. 65(2):117-122, 2019 Feb.
501			_aAvailable online from MWHC library: 2000 - present, Available in print through MWHC library: 1999 - 2003
520			_aCardiac resynchronization therapy (CRT) and left ventricular assist devices (LVADs) are common heart failure therapies; however, little is known regarding the concomitant use of these devices. We aim to evaluate unloading differences in LVAD patients with and without active biventricular pacing. Left ventricular assist device patients with and without CRT prospectively underwent ramp hemodynamic/echocardiographic testing. Patients with >95% biventricular pacing comprised the active CRT pacing group; all others (no device, implantable cardioverter defibrillator only, CRT without biventricular pacing) were categorized into the non-CRT pacing group. Invasive hemodynamics and echocardiographic characteristics (left ventricular end-diastolic/systolic diameter and valvular regurgitation) were measured at baseline and at incremental speed changes. Unloading slopes were calculated using linear regression modeling for individual hemodynamics and echocardiographic characteristics across speeds. Among 62 LVAD patients (age 59.6 +/- 11.4 years, 60% male), 25 had active CRT pacing. There was no significant difference in echocardiographic or hemodynamic characteristics at baseline or final set speeds between CRT groups. Similarly, no significant differences were noted in the unloading characteristics. In LVAD patients, active biventricular pacing is unlikely to improve echocardiographic or hemodynamic characteristics.
546			_aEnglish
650			_a*Cardiac Resynchronization Therapy/mt [Methods]
650			_a*Heart Failure/th [Therapy]
650			_a*Heart Ventricles/pp [Physiopathology]
650			_a*Heart-Assist Devices
650			_aAged
650			_aFemale
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aTreatment Outcome
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aGrinstein, Jonathan
790			_aAdatya S, Grinstein J, Kim GH, Raikhelkar J, Rodgers D, Sarswat N, Sayer G, Tehrani DM, Uriel N
856			_uhttps://dx.doi.org/10.1097/MAT.0000000000000787 _zhttps://dx.doi.org/10.1097/MAT.0000000000000787
942			_cART _dArticle
999			_c4164 _d4164