000			03345nam a22005657a 4500
008			190521s20192019 xxu||||| |||| 00| 0 eng d
022			_a1751-2972
024			_a10.1111/1751-2980.12750 [doi]
040			_aOvid MEDLINE(R)
099			_a30969003
245			_aSafety and efficacy of fecal microbiota transplant in 9 critically ill patients with severe and complicated Clostridium difficile infection with impending colectomy.
251			_aJournal of Digestive Diseases. 20(6):301-307, 2019 Jun.
252			_aJ Dig Dis. 20(6):301-307, 2019 Jun.
252			_zJ Dig Dis. 2019 Apr 10
253			_aJournal of digestive diseases
260			_c2019
260			_fFY2019
265			_saheadofprint
265			_sppublish
266			_d2019-05-21
268			_aJournal of Digestive Diseases. 2019 Apr 10
520			_aCONCLUSION: Our success with FMT in fulminant CDI shows that this therapeutic modality is a promising alternative to a colectomy and could be a potential bowel-saving intervention.
520			_aCopyright (c) 2019 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.
520			_aMETHODS: This was a 2-center study of 9 patients who met the criteria for severe and complicated CDI and had an impending colectomy. All 9 patients had failed conventional antibiotic therapy and were deemed too unstable to undergo a colectomy. Hence, FMT was considered to be the next step in managing their condition.
520			_aOBJECTIVE: Significant data support the efficacy and safety of fecal microbiota transplant (FMT) in recurrent Clostridium difficile infection (CDI). The objective of our study was to determine the success rate of FMT in patients diagnosed with severe and complicated CDI with impending colectomy in the intensive care setting.
520			_aRESULTS: Following FMT there was marked improvement in the patients' clinical status, with the resolution of diarrhea, reduced requirement for vasopressor, and the reduction in abdominal distention and pain. The primary cure rate of our study after a single round of FMT was 78% (7/9). Of the 9 patients 8 (88.88%) avoided a colectomy during the same hospital admission. the CDI-related death rate was 12.5% (1/9) and that of non-CDI was 12.5% (1/9).
546			_aEnglish
650			_a*Clostridium difficile
650			_a*Colectomy
650			_a*Enterocolitis, Pseudomembranous/th [Therapy]
650			_a*Fecal Microbiota Transplantation/mt [Methods]
650			_a*Preoperative Care/mt [Methods]
650			_aAged
650			_aCritical Illness/th [Therapy]
650			_aEnterocolitis, Pseudomembranous/mi [Microbiology]
650			_aFemale
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aRecurrence
650			_aTreatment Outcome
651			_aMedStar Washington Hospital Center
656			_aMedicine/Gastroenterology
657			_aJournal Article
700			_aMattar, Mark C
700			_aTabbaa, Obada
790			_aAlukal J, Dutta SK, Le M, Mattar MC, Philips L, Surapaneni BK, Tabbaa O
856			_uhttps://dx.doi.org/10.1111/1751-2980.12750 _zhttps://dx.doi.org/10.1111/1751-2980.12750
942			_cART _dArticle
999			_c4197 _d4197