000			03019nam a22005177a 4500
008			190827s20212021 xxu||||| |||| 00| 0 eng d
022			_a0735-1631
024			_a10.1055/s-0039-1694730 [doi]
040			_aOvid MEDLINE(R)
099			_a31412405
245			_aRespiratory and Hemodynamic Changes in Neonates with Hypoxic-Ischemic Encephalopathy during and after Whole-Body Hypothermia.
251			_aAmerican Journal of Perinatology. 38(1):37-43, 2021 01.
252			_aAm J Perinatol. 38(1):37-43, 2021 01.
252			_zAm J Perinatol. 2019 Aug 14
253			_aAmerican journal of perinatology
260			_c2021
260			_fFY2021
265			_saheadofprint
265			_sppublish
266			_d2019-08-27
268			_aAmerican Journal of Perinatology. 2019 Aug 14
269			_fFY2020
520			_aCONCLUSION: There was a decrease in metabolic demand as measured by oxygen requirement, OI, HR, and MBP during WBH, but only HR increased during rewarming, with no significant change in the other parameters. Some of this effect may be explained by improvement in the respiratory condition over time.
520			_aCopyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
520			_aOBJECTIVE: To determine the degree to which whole-body hypothermia (WBH) impacts hemodynamic and respiratory status during hypothermia and the subsequent rewarming period in neonates with hypoxic-ischemic encephalopathy (HIE).
520			_aRESULTS: HR decreased during WBH and significantly increased during rewarming. Lactate level, OI, VEI, FiO<sub>2</sub>, and MBP all decreased during WBH but showed no significant change during and after rewarming.
520			_aSTUDY DESIGN: This is a retrospective study reviewing the medical records of infants treated with WBH. Data including oxygenation index (OI), ventilator efficiency index (VEI), fraction of inspired oxygen (FiO<sub>2</sub>), blood lactate level, heart rate (HR), and mean blood pressure (MBP) were collected from defined time points from the beginning, middle, and end of WBH and then every 2 hours from the beginning of rewarming for 14 hours thereafter. The analysis included 65 infants. Data were analyzed using a piecewise linear regression with a mixed-effect model.
546			_aEnglish
650			_a*Hemodynamics
650			_a*Hypothermia, Induced
650			_a*Hypoxia-Ischemia, Brain/pp [Physiopathology]
650			_a*Respiration
650			_aHumans
650			_aHypoxia-Ischemia, Brain/th [Therapy]
650			_aInfant, Newborn
650			_aLinear Models
650			_aOxygen Consumption/ph [Physiology]
650			_aOxygen/bl [Blood]
650			_aRetrospective Studies
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aDesale, Sameer
790			_aAbubakar K, Desale S, Sheppard SR
856			_uhttps://dx.doi.org/10.1055/s-0039-1694730 _zhttps://dx.doi.org/10.1055/s-0039-1694730
942			_cART _dArticle
999			_c4545 _d4545