000			04071nam a22005897a 4500
008			191119s20192019 xxu||||| |||| 00| 0 eng d
022			_a0363-5023
024			_a10.1016/j.jhsa.2019.10.004 [doi]
024			_aS0363-5023(19)31392-9 [pii]
040			_aOvid MEDLINE(R)
099			_a31677909
245			_aCoronary Artery Disease Association With Arterial Calcifications on Routine Hand Radiographs.
251			_aJournal of Hand Surgery - American Volume. 44(12):1060-1065, 2019 Dec.
252			_aJ Hand Surg [Am]. 44(12):1060-1065, 2019 Dec.
252			_zJ Hand Surg [Am]. 2019 Oct 30
253			_aThe Journal of hand surgery
260			_c2019
260			_fFY2020
265			_saheadofprint
265			_sppublish
266			_d2019-11-19
268			_aJournal of Hand Surgery - American Volume. 2019 Oct 30
501			_aAvailable in print through MWHC library: 1999 - 2002, Available online from MWHC library: 1995 - present
520			_aCONCLUSIONS: The current data demonstrate that arterial calcifications on hand radiographs are independently associated with CAD. This may represent an opportunity to the treating physician as a point of referral or investigation for underlying or occult CAD.
520			_aMETHODS: A record review from a single institution identified 345 patients with both hand radiographs and CAD screening with cardiac stress testing or coronary angiography. Patients with chronic kidney disease, end-stage renal disease, or incomplete hand films were excluded. We reviewed x-rays for findings of arterial calcifications. Cardiac testing results were used to establish a baseline diagnosis of CAD. We made group comparisons and employed multivariable logistic regression to evaluate the association between upper-extremity calcification and CAD.
520			_aPURPOSE: Arterial calcifications in the lower extremity, chest, and cardiac vessels have been linked to coronary artery disease (CAD). However, the relation between arterial calcifications observed on routine hand and upper-extremity radiographs and atherosclerosis has not been determined. This study examined whether arterial calcifications found on hand radiographs are associated with CAD.
520			_aRESULTS: A total of 210 patients met inclusion criteria: 155 with CAD and 55 without it. Mean age was 72 years, body mass index was 28.8, and 54% were male. Patients had comorbidities of hypertension (91%), hyperlipidemia (87%), diabetes (39%), cerebrovascular accident (9%), and a history of tobacco use (53%). Of 155 CAD patients, 67 had arterial calcifications on hand radiographs (43%), compared with 6 of 55 without it (11%). In a multivariable model controlling for sex, hyperlipidemia, and diabetes, the presence of arterial calcifications on hand plain films indicated a 6.2-fold increased odds of CAD.
520			_aTYPE OF STUDY/LEVEL OF EVIDENCE: Prevalence III. Copyright (c) 2019 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
546			_aEnglish
650			_a*Coronary Artery Disease/di [Diagnosis]
650			_a*Hand/bs [Blood Supply]
650			_a*Hand/dg [Diagnostic Imaging]
650			_a*Vascular Calcification/dg [Diagnostic Imaging]
650			_aAdult
650			_aAged
650			_aAged, 80 and over
650			_aCoronary Angiography
650			_aExercise Test
650			_aFemale
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aRetrospective Studies
650			_aRisk Factors
651			_aCurtis National Hand Center
657			_aJournal Article
700			_aGiladi, Aviram M
790			_aGiladi AM, Hall EC, Iorio ML, Ruan Q, Taylor EM, Wu WW
856			_uhttps://dx.doi.org/10.1016/j.jhsa.2019.10.004 _zhttps://dx.doi.org/10.1016/j.jhsa.2019.10.004 _zhttps://dx.doi.org/10.1016/j.jhsa.2019.10.004
856			_uhttps://dx.doi.org/10.1016/j.jhsa.2019.10.004 _zhttps://dx.doi.org/10.1016/j.jhsa.2019.10.004 _zhttps://dx.doi.org/10.1016/j.jhsa.2019.10.004
942			_cART _dArticle
999			_c4728 _d4728