000 02447nam a22003257a 4500
008 200826s20202020 xxu||||| |||| 00| 0 eng d
022 _a1865-7265
024 _a10.1007/s12328-020-01146-z [doi]
024 _a10.1007/s12328-020-01146-z [pii]
040 _aOvid MEDLINE(R)
099 _a32583372
245 _aRobot-assisted combined pancreatectomy/hepatectomy for metastatic pancreatic acinar cell carcinoma: case report and review of the literature.
251 _aClinical Journal of Gastroenterology. 2020 Jun 25
252 _aClin J Gastroenterol. 2020 Jun 25
253 _aClinical journal of gastroenterology
260 _c2020
260 _fFY2020
265 _saheadofprint
266 _d2020-08-26
520 _aAcinar cell carcinoma (ACC) of the pancreas is a rare neoplasm with less aggressive behavior than ductal carcinoma. As a result, surgical resection for metastatic ACC is a therapeutic option which can result in long-term survival. There is a paucity of data describing institutional approaches to these challenging patients, and therefore, we herein describe our institution's approach to a patient with a distal pancreatic ACC and isolated liver metastasis. The patient underwent neoadjuvant chemotherapy (FOLFIRINOX), followed by a robot-assisted distal pancreatectomy/splenectomy and non-anatomic segment 6 resection. He was discharged to home post-operative day 2. Final pathology revealed complete tumor response of the liver metastasis and a margin negative resection of the primary tumor. He remains disease free and without complications at 3 months. We highlight that combined modality therapy for metastatic ACC can yield long-term survival in selected patients. Similarly, the robotic platform enables performance of complex multivisceral resections with rapid recovery. Future research investigating precision medicine for metastatic ACC is warranted given widely variable tumor biology in this disease.
546 _aEnglish
650 _aIN PROCESS -- NOT YET INDEXED
651 _aMedStar Washington Hospital Center
656 _aSurgery/General Surgery
657 _aJournal Article
700 _aVillano, Anthony M
790 _aBarrak D, Chalhoub W, Fishbein T, Haddad N, Hawksworth J, Jain A, Meslar E, Radkani P, Villano AM, Winslow E
856 _uhttps://dx.doi.org/10.1007/s12328-020-01146-z
_zhttps://dx.doi.org/10.1007/s12328-020-01146-z
942 _cART
_dArticle
999 _c5273
_d5273