000			03073nam a22004817a 4500
008			200902s20202020 xxu||||| |||| 00| 0 eng d
022			_a1559-047X
024			_a10.1093/jbcr/iraa132 [doi]
024			_a5896541 [pii]
040			_aOvid MEDLINE(R)
099			_a32835360
245			_aComing to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models?.
251			_aJournal of Burn Care & Research. 42(1):98-109, 2021 02 03.
252			_aJ Burn Care Res. 42(1):98-109, 2021 02 03.
252			_zJ Burn Care Res. 2020 Aug 24
253			_aJournal of burn care & research : official publication of the American Burn Association
260			_c2021
260			_fFY2021
265			_saheadofprint
265			_sppublish
266			_d2020-09-02
268			_aJournal of Burn Care & Research. 2020 Aug 24
269			_fFY2021
520			_aDeep partial thickness burns are clinically prevalent and difficult to diagnose. In order to develop methods to assess burn depth and therapies to treat deep partial thickness burns, reliable, accurate animal models are needed. The variety of animal models in the literature and the lack of precise details reported for the experimental procedures makes comparison of research between investigators challenging, and ultimately impacts translation to patients. We sought to compare deep partial thickness porcine burn models from five well-established laboratories. In doing so, we uncovered a lack of consistency in approaches to the evaluation of burn injury depth that was present within and among various models. We then used an iterative process to develop a scoring rubric with an educational component to facilitate burn injury depth evaluation that improved reliability of the scoring. Using the developed rubric to re-score the five burn models, we found that all models created a deep partial thickness injury and that agreement about specific characteristics identified on histologic staining was improved. Finally, we present consensus statements on the evaluation and interpretation of the microanatomy of deep partial thickness burns in pigs. Copyright (c) The Author(s) 2020. Published by Oxford University Press on behalf of the American Burn Association.
546			_aEnglish
650			_a*Burns/cl [Classification]
650			_a*Consensus
650			_a*Disease Models, Animal
650			_aAnimals
650			_aHumans
650			_aSwine
651			_aMedStar Health Research Institute
651			_aMedStar Washington Hospital Center
656			_aFirefighters' Burn and Surgical Research Laboratory
656			_aSurgery/Burn Services
657			_aJournal Article
700			_aCarney, Bonnie C
700			_aMoffatt, Lauren T
700			_aShupp, Jeffrey W
790			_aAndrews CJ, Carney BC, Cuttle L, Gibson ALF, Kowalczewski CJ, Lily S, Liu A, Moffatt LT, Powell HM, Shupp JW, Singer AJ, Stone R, Supp DM
856			_uhttps://dx.doi.org/10.1093/jbcr/iraa132 _zhttps://dx.doi.org/10.1093/jbcr/iraa132
942			_cART _dArticle
999			_c5379 _d5379