000			03323nam a22005897a 4500
008			200902s20202020 xxu||||| |||| 00| 0 eng d
022			_a1056-8727
024			_a10.1016/j.jdiacomp.2020.107678 [doi]
024			_aS1056-8727(20)30440-2 [pii]
040			_aOvid MEDLINE(R)
099			_a32718559
245			_aBlood pressure during sleep is associated with arterial stiffness and urine microalbumin to creatinine ratio in youth with type 1 diabetes.
251			_aJournal of Diabetes & its Complications. 34(11):107678, 2020 11.
252			_aJ Diabetes Complications. 34(11):107678, 2020 11.
252			_zJ Diabetes Complications. :107678, 2020 Jul 18
253			_aJournal of diabetes and its complications
260			_c2020
260			_fFY2021
265			_saheadofprint
265			_sppublish
266			_d2020-09-02
268			_aJournal of Diabetes & its Complications. :107678, 2020 Jul 18
269			_fFY2021
520			_aAIMS: To determine whether sleep blood pressure (BP) is associated with increased cardiovascular disease (CVD) risk in youth with type 1 diabetes (T1DM).
520			_aCONCLUSIONS: Blood pressure alterations during sleep are common in youth with T1DM and they are associated with arterial stiffness and UAC. Larger studies are needed to confirm our results and examine whether interventions that target sleep and night-time BP could decrease CVD risk. Copyright (c) 2020 Elsevier Inc. All rights reserved.
520			_aMETHODS: We enrolled youth with T1DM, 12-21years old. Carotid-femoral Pulse Wave Velocity (PWVcf) assessed arterial stiffness, a CVD marker. Sleep systolic and diastolic BP variables were obtained from 24-hour BP Monitoring. Linear regression models analyzed the relationship of each BP variable with PWVcf, adjusted for HbA1c. Correlation of sleep BP with urine microalbumin-to-creatinine ratio (UAC) was examined.
520			_aRESULTS: Nocturnal hypertension was found in 36% and abnormal dipping in 48% of the 25 participants, aged 17.7+/-2.2years old. Sleep systolic BP [beta=0.039, 95% Confidence Interval (CI; 0.006-0.073)], diastolic BP [beta=0.058, 95% CI (0.003-0.114)], Mean Arterial Pressure (MAP) [beta=0.075, 95% CI (0.018-0.131)] and MAP index [beta=3.547, 95% CI (0.867-6.227)] were significantly associated with PWVcf. Sleep diastolic BP, load, MAP correlated with UAC.
546			_aEnglish
650			_a*Blood Pressure
650			_a*Diabetes Mellitus, Type 1
650			_a*Hypertension
650			_a*Sleep
650			_a*Vascular Stiffness
650			_aAdolescent
650			_aAlbuminuria
650			_aBlood Pressure Monitoring, Ambulatory
650			_aChild
650			_aCircadian Rhythm
650			_aCreatinine/ur [Urine]
650			_aDiabetes Mellitus, Type 1/co [Complications]
650			_aHumans
650			_aHypertension/co [Complications]
650			_aHypertension/ep [Epidemiology]
650			_aPulse Wave Analysis
650			_aYoung Adult
651			_aMedStar Health Research Institute
657			_aJournal Article
700			_aMete, Mihriye
790			_aBrady T, Cogen F, Dimatulac M, Gourgari E, Mete M
856			_uhttps://dx.doi.org/10.1016/j.jdiacomp.2020.107678 _zhttps://dx.doi.org/10.1016/j.jdiacomp.2020.107678
942			_cART _dArticle
999			_c5432 _d5432