000			02090nam a22003257a 4500
008			200902s20202020 xxu||||| |||| 00| 0 eng d
022			_a2168-8184
024			_a10.7759/cureus.8883 [doi]
024			_aPMC7388802 [pmc]
040			_aOvid MEDLINE(R)
099			_a32742850
245			_aWhen Anti-Neutrophil Cytoplasmic Antibody Fails: A Case of Anti-Neutrophil Cytoplasmic Antibody Negative Granulomatosis With Polyangiitis.
251			_aCureus. 12(6):e8883, 2020 Jun 28.
252			_aCureus. 12(6):e8883, 2020 Jun 28.
253			_aCureus
260			_c2020
260			_fFY2020
265			_sepublish
266			_d2020-09-02
520			_aGranulomatosis with polyangiitis (GPA) is a vasculitis of small and medium-sized vessels and presents with varying signs and symptoms. It includes upper and lower airway manifestations and glomerulonephritis with a positive antineutrophil cytoplasmic antibody (ANCA) in serology in 90% of cases. However, about 10% of cases with GPA can have negative serology, often resulting in a diagnostic delay. Obtaining a tissue pathology is needed to confirm GPA. Here we present a 77-year-old male who presented with generalized weakness and loss of appetite and was found to have glomerulonephritis and bilateral opacities in the lungs with a negative ANCA. He was diagnosed with ANCA negative granulomatosis with polyangiitis after a renal biopsy revealed necrotizing inflammation with crescent formation. He was successfully treated with systemic glucocorticoids and rituximab. In conclusion, prompt diagnosis and treatment of ANCA negative vasculitis are required to decrease mortality. Copyright (c) 2020, Gangireddy et al.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Franklin Square Medical Center
656			_aMedicine
657			_aCase Reports
700			_aKundoor, Vishwa
790			_aChan Gomez J, Cunningham J, Gangireddy M, Kanderi T, Kundoor V
856			_uhttps://dx.doi.org/10.7759/cureus.8883 _zhttps://dx.doi.org/10.7759/cureus.8883
942			_cART _dArticle
999			_c5502 _d5502