000			02992nam a22003377a 4500
008			200902s20202020 xxu||||| |||| 00| 0 eng d
022			_a2168-8184
024			_a10.7759/cureus.9195 [doi]
024			_aPMC7366047 [pmc]
040			_aOvid MEDLINE(R)
099			_a32685328
245			_aThe Impact of Clostridium Difficile Infections on In-Hospital Outcomes of Venous Thromboembolism (Deep Vein Thrombosis or Pulmonary Embolism) Hospitalizations.
251			_aCureus. 12(7):e9195, 2020 Jul 15.
252			_aCureus. 12(7):e9195, 2020 Jul 15.
253			_aCureus
260			_c2020
260			_fFY2021
265			_sepublish
266			_d2020-09-02
520			_aBackground Clostridium difficile infection (CDI) is associated with high mortality. Studies have shown an increased rate of venous thromboembolism (VTE) in patients with CDI. However, literature regarding the impact of CDI on outcomes of VTE-related hospitalizations is scarce. Our study aimed to assess the impact of CDI on in-hospital outcomes among VTE hospitalizations. Methods The 2016 National Inpatient Sample (NIS) was used to identify all adult hospitalizations in the United States with a primary discharge diagnosis of acute VTE. Hospitalizations with deep vein thrombosis (DVT) or pulmonary embolism (PE) were included under VTE. The sample was stratified based on the presence or absence of active CDI. Chi-square test and weighted Student's t-test were used to analyze categorical and continuous variables, respectively. The adjusted odds ratio (OR) for clinical outcomes were calculated using multivariate logistic regression analysis. Subgroup analyses for DVT and PE hospitalizations were performed. All analyses were completed in SAS (SAS Institute Inc., Cary, NC), and a p-value of <0.05 was considered statistically significant. Results We identified 382,585 weighted hospitalizations for VTE. Among them, 0.8% had concomitant CDI. The presence of CDI was associated with a statistically significant increase in in-hospital mortality (6% vs. 3%), hospitalization cost ( _147,356.5 vs. _55,193), and length of stay (13.7 vs. 5.4 days). There were more incidents of bleeding and acute respiratory failure requiring prolonged ventilation in patients with CDI. The odds of stroke were significantly higher in patients with CDI and DVT. Conclusion CDI independently increased in-hospital mortality in VTE. Preventing CDI in the VTE population may mitigate complications, improve in-hospital outcomes, and reduce treatment costs. Copyright (c) 2020, Jhaveri et al.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Washington Hospital Center
656			_aMedicine/Internal Medicine
657			_aJournal Article
700			_aJhaveri, Khushali
700			_aSom, Aniruddh
790			_aJhaveri K, Padala SA, Som A, Surani S
856			_uhttps://dx.doi.org/10.7759/cureus.9195 _zhttps://dx.doi.org/10.7759/cureus.9195
942			_cART _dArticle
999			_c5520 _d5520