000			03136nam a22004577a 4500
008			201006s20202020 xxu||||| |||| 00| 0 eng d
022			_a0267-6591
024			_a10.1177/0267659120956534 [doi]
040			_aOvid MEDLINE(R)
099			_a32909513
245			_aA proposed redosing interval of del Nido cardioplegia solution in adult cardiac surgery: a propensity-matched study.
251			_aPerfusion. 36(5):463-469, 2021 Jul.
252			_aPerfusion. 36(5):463-469, 2021 Jul.
252			_zPerfusion. :267659120956534, 2020 Sep 10
253			_aPerfusion
260			_c2021
260			_fFY2022
265			_saheadofprint
265			_sppublish
266			_d2020-10-06
268			_aPerfusion. :267659120956534, 2020 Sep 10
520			_aBACKGROUND: Recently, del Nido cardioplegia solution (DN) has been utilized in adult cardiac surgery. However, adequate interval of maintenance dose(s) is still unclear. The purpose of this study was to assess the safety and efficacy of our DN protocol by comparing with conventional cold whole blood cardioplegia (CWB).
520			_aCONCLUSIONS: Short-term clinical outcomes in the patients underwent cardiovascular surgery with the DN protocol including the redosing interval strategy were acceptable. Also, DN protocol was associated with shortened cross-clamp time and less usage of the retrograde cannula.
520			_aMETHODS: A total of 1003 consecutive patients (DN group, N = 350 vs. CWB group, N = 653) underwent cardiovascular surgery between July 2013 and September 2018 were included in this study. The DN protocol was to administer 1000 to 1200 ml as an initial dose and to add maintenance dose(s) (500 ml each) every 60 minutes when the estimated cross-clamp time was over 90 minutes. CWB was given every 20 minutes, regardless of cross-clamp time. Propensity matching identified 254 matched pairs for analysis. The preoperative and postoperative data were reviewed.
520			_aRESULTS: Cross-clamp time was significantly shorter in the DN group compared with the CWB group (107 +/- 56 minutes vs. 116 +/- 49 minutes, p = 0.0458). A retrograde cannula was used in 124 (48.8%) patients in the DN group and 181 (71.3%) patients in the CWB group (p < 0.0001). There were no significant differences in requiring postoperative cardiac supports (inotropes, mechanical circulatory supports) and major complications. In-hospital mortality was similar between two groups (DN group: 3.2% vs. CWB group: 2.4%, p = 0.5872).
546			_aEnglish
650			_a*Cardiac Surgical Procedures
650			_a*Cardioplegic Solutions
650			_aAdult
650			_aCardioplegic Solutions/tu [Therapeutic Use]
650			_aHeart Arrest, Induced
650			_aHumans
650			_aPostoperative Period
650			_aRetrospective Studies
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aKitahara, Hiro
790			_aJeevanandam V, Kitahara H, Koda Y, Nishida H, Ota T
856			_uhttps://dx.doi.org/10.1177/0267659120956534 _zhttps://dx.doi.org/10.1177/0267659120956534
942			_cART _dArticle
999			_c5583 _d5583