000			03987nam a22006017a 4500
008			201229s20202020 xxu||||| |||| 00| 0 eng d
022			_a1878-0938
024			_a10.1016/j.carrev.2020.07.023 [doi]
024			_aS1553-8389(20)30449-8 [pii]
040			_aOvid MEDLINE(R)
099			_a33097462
245			_aNatural History of Adapted Leaman Score Assessing Coronary Artery Disease Progression by Computed Tomography Angiography: A 7-Year Follow-Up Report.
251			_aCardiovascular Revascularization Medicine. 27:38-44, 2021 06.
252			_aCardiovasc Revasc Med. 27:38-44, 2021 06.
252			_zCardiovasc Revasc Med. 2020 Jul 26
253			_aCardiovascular revascularization medicine : including molecular interventions
260			_c2021
260			_fFY2021
265			_saheadofprint
265			_sppublish
266			_d2020-12-29
268			_aCardiovascular Revascularization Medicine. 2020 Jul 26
269			_fFY2021
501			_aAvailable in print through MWHC library: 2002 - present
520			_aBACKGROUND: Coronary computed tomographic angiography (CCTA) provides a non-invasive assessment of the coronary artery tree. Computed Tomography - adapted Leaman Score (CT-LeSc) has been shown to be an independent predictor of cardiac events in coronary artery disease (CAD) patients with a score greater than 5 (high).
520			_aCONCLUSION: In patients at high-risk for cardiac events, as determined by CT-LeSc, there was an increase in CT-LeSc, obstructive lesions, and calcified plaques over the 7-year follow-up period. Most of the new lesions were obstructive and non-calcified. This is the first report showing long term serial imaging CCTA changes in a high-risk population. Copyright (c) 2020 Elsevier Inc. All rights reserved.
520			_aMETHODS: Patients with multivessel CAD and CCTA assessments at baseline and follow-up were included. The CT-LeSc analysis was performed in a paired fashion. The patient-level scores and the differences between each phase were assessed by 2 analysts in an independent CoreLab.
520			_aPURPOSE: To investigate the relationship between CT-LeSc and the progression of CAD and to provide vessel- and segment-level CAD qualification and quantification at baseline and 7-year follow-up.
520			_aRESULTS: This study analyzed 248 coronary segments from 17 patients with a mean follow-up interval of 7.5 +/- 0.6 years. The mean CT-LeSc at baseline and follow-up were 14.6 +/- 4.2 and 16.9 +/- 1.5, respectively, with an absolute increase of 2.3 +/- 1.8. The mean cumulative increase of new lesions was 0.2 +/- 0.2 per year. Over time, 14.6% of the non-obstructive lesions became obstructive, and 15.0% of the non-calcified plaques became calcified. There were 29 new lesions found at follow-up, and out of these, 16 were obstructive and 19 were non-calcified.
546			_aEnglish
650			_a*Coronary Artery Disease
650			_a*Coronary Stenosis
650			_a*Plaque, Atherosclerotic
650			_aComputed Tomography Angiography
650			_aCoronary Angiography
650			_aCoronary Artery Disease/dg [Diagnostic Imaging]
650			_aFollow-Up Studies
650			_aHumans
650			_aPredictive Value of Tests
650			_aRisk Assessment
650			_aTomography, X-Ray Computed
651			_aMedStar Heart & Vascular Institute
651			_aMedStar Washington Hospital Center
657			_aJournal Article
700			_aDan, Kazuhiro
700			_aGarcia-Garcia, Hector M
700			_aHideo-Kajita, Alexandre
700			_aOzaki, Yuichi
700			_aWopperer, Samuel
790			_aBittencourt M, Cavalcante R, Dan K, Falcao BAA, Falcao JLA, Freire AFD, Garcia-Garcia HM, Hideo-Kajita A, Lemos PA, Ozaki Y, Pinheiro TL, Ribeiro E, Rochitte CE, Rubarth R, Soares P, Wopperer S
856			_uhttps://dx.doi.org/10.1016/j.carrev.2020.07.023 _zhttps://dx.doi.org/10.1016/j.carrev.2020.07.023
942			_cART _dArticle
999			_c5867 _d5867