000			02753nam a22003737a 4500
008			201229s20202020 xxu||||| |||| 00| 0 eng d
022			_a2168-8184
024			_a10.7759/cureus.10900 [doi]
024			_aPMC7550245 [pmc]
040			_aOvid MEDLINE(R)
099			_a33062459
245			_aStandardized Platelet Rich Plasma Injections for Osteoarthritis of the Knee.
251			_aCureus. 12(10):e10900, 2020 Oct 11.
252			_aCureus. 12(10):e10900, 2020 Oct 11.
253			_aCureus
260			_c2020
260			_fFY2021
265			_sepublish
266			_d2020-12-29
520			_aObjective Platelet-rich plasma (PRP) and adipose-derived stem cells (ADSC) injections are non-surgical treatments for knee osteoarthritis (OA). The purpose of this study is to assess the effectiveness of serial PRP with or without ADSC injections in the treatment of refractory OA of the knee. Design Patients who failed to achieve pain relief with conventional non-surgical treatments, with Kellgren-Lawrence grade 3 or 4 knee OA, were recruited from a private outpatient clinic. Over 67 patients were elected to receive serial PRP injections and 22 patients were elected to receive an ADSC+PRP injection. These patients completed Western Ontario and McMaster Universities Arthritis Index (WOMAC) surveys prior to each treatment and at follow-up appointments. These surveys were retrospectively reviewed to assess changes in functional status and pain over time. Results Twenty-nine patients from the PRP group and eight patients in the ADSC+PRP group had adequate follow-up for inclusion in the analysis. The PRP group had an improvement in WOMAC scores by 34.30%, 60.2%, and 58.5% for patients reporting at 1-3, 4-6, and >6 months of follow-up. The ADSC+PRP group experienced an improvement of 51% at an average of 4.66 months of follow-up. Conclusions Serial PRP injections and a single ADSC+PRP injection yield improved and sustained functional outcome scores for patients with severe, refractory OA of the knee. Future studies should consider consistent orthobiologic preparation protocols to ensure reproducibility. Copyright (c) 2020, Ehlers et al.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Union Memorial Hospital
651			_aMedStar Washington Hospital Center
656			_aMedicine/Rheumatology
656			_aOrthopaedics
657			_aJournal Article
700			_aMarano, Geoffrey
700			_aMcCormick, Brian P
700			_aSchainker, Lawrence
790			_aEhlers CB, Marano G, McCormick BP, Povey K, Sarna N, Schainker L, Webb AR, Wyand TJ
856			_uhttps://dx.doi.org/10.7759/cureus.10900 _zhttps://dx.doi.org/10.7759/cureus.10900
942			_cART _dArticle
999			_c5915 _d5915