000			04581nam a22007217a 4500
008			201231s20202020 xxu||||| |||| 00| 0 eng d
022			_a2328-9503
024			_a10.1002/acn3.51243 [doi]
024			_aPMC7732242 [pmc]
040			_aOvid MEDLINE(R)
099			_a33216462
245			_aCardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies.
251			_aAnnals of Clinical & Translational Neurology. 7(12):2450-2460, 2020 12.
252			_aAnn. clin. transl. neurol.. 7(12):2450-2460, 2020 12.
252			_zAnn. clin. transl. neurol.. 2020 Nov 20
253			_aAnnals of clinical and translational neurology
260			_c2020
260			_fFY2021
265			_saheadofprint
265			_sppublish
266			_d2020-12-31
268			_aAnnals of Clinical & Translational Neurology. 2020 Nov 20
269			_fFY2021
520			_aINTERPRETATION: By in vivo sympathetic neuroimaging and postmortem neurochemistry peripheral noradrenergic deficiency in LB synucleinopathies is cardioselective. MSA does not involve peripheral noradrenergic deficiency. Copyright (c) 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
520			_aMETHODS: 18 F-DA-derived radioactivity in the heart, liver, spleen, pancreas, stomach, kidneys, thyroid, and submandibular glands were analyzed from 145 patients with LB synucleinopathies (112 PD, 33 PAF), 74 controls, and 85 MSA patients. In largely separate cohorts, postmortem tissue norepinephrine data were reviewed for heart, liver, spleen, pancreas, kidney, thyroid, submandibular gland, and sympathetic ganglion tissue from 38 PD, 2 PAF, and 5 MSA patients and 35 controls.
520			_aOBJECTIVE: Lewy body (LB) synucleinopathies such as Parkinson's disease (PD) entail profound cardiac norepinephrine deficiency. The status of sympathetic noradrenergic innervation at other extracranial sites has been unclear. Although in vivo neuroimaging studies have indicated a cardioselective noradrenergic lesion, no previous study has surveyed peripheral organs for norepinephrine contents in LB diseases. We reviewed 18 F-dopamine (18 F-DA) positron emission tomographic images and postmortem neurochemical data across several body organs of controls and patients with the LB synucleinopathies PD and pure autonomic failure (PAF) and the non-LB synucleinopathy multiple system atrophy (MSA).
520			_aRESULTS: Interventricular septal 18 F-DA-derived radioactivity was decreased in the LB synucleinopathy group compared to the control and MSA groups (P < 0.0001 each). The LB and non-LB groups did not differ in liver, spleen, pancreas, stomach, or kidney 18 F-DA-derived radioactivity. The LB synucleinopathy group had markedly decreased apical myocardial norepinephrine, but normal tissue norepinephrine in other organs. The MSA group had normal tissue norepinephrine in all examined organs.
546			_aEnglish
650			_a*Dopamine/pk [Pharmacokinetics]
650			_a*Heart/dg [Diagnostic Imaging]
650			_a*Lewy Body Disease/me [Metabolism]
650			_a*Multiple System Atrophy/me [Metabolism]
650			_a*Myocardium/me [Metabolism]
650			_a*Norepinephrine/me [Metabolism]
650			_a*Parkinson Disease/me [Metabolism]
650			_a*Pure Autonomic Failure/me [Metabolism]
650			_a*Sympathetic Nervous System/me [Metabolism]
650			_aAged
650			_aAutopsy
650			_aFemale
650			_aFluorine Radioisotopes
650			_aHeart Septum/dg [Diagnostic Imaging]
650			_aHeart Septum/me [Metabolism]
650			_aHeart Ventricles/dg [Diagnostic Imaging]
650			_aHeart Ventricles/me [Metabolism]
650			_aHeart/ir [Innervation]
650			_aHumans
650			_aLewy Body Disease/dg [Diagnostic Imaging]
650			_aMale
650			_aMiddle Aged
650			_aMultiple System Atrophy/dg [Diagnostic Imaging]
650			_aParkinson Disease/dg [Diagnostic Imaging]
650			_aPositron-Emission Tomography
650			_aPure Autonomic Failure/dg [Diagnostic Imaging]
650			_aSympathetic Nervous System/dg [Diagnostic Imaging]
651			_aMedStar Washington Hospital Center
656			_aNeurology
657			_aJournal Article
700			_aLenka, Abhishek
790			_aGoldstein DS, Holmes C, Lamotte G, Lenka A, Sullivan P
856			_uhttps://dx.doi.org/10.1002/acn3.51243 _zhttps://dx.doi.org/10.1002/acn3.51243
942			_cART _dArticle
999			_c5940 _d5940