000			03193nam a22004097a 4500
008			210217s20212021 xxu||||| |||| 00| 0 eng d
022			_a0026-4725
024			_a10.23736/S0026-4725.20.05386-4 [doi]
024			_aS0026-4725.20.05386-4 [pii]
040			_aOvid MEDLINE(R)
099			_a33427420
245			_aLeft ventricular global longitudinal strain assessment in patients with Takotsubo Cardiomyopathy: a call for an echocardiography-based classification.
251			_aMinerva Cardioangiologica. 2021 Jan 11
252			_aMinerva Cardioangiol. 2021 Jan 11
253			_aMinerva cardioangiologica
260			_c2021
260			_fFY2021
265			_saheadofprint
266			_d2021-02-17
520			_aBACKGROUND: Takotsubo Cardiomyopathy (TTC) is classified into 4 types dependent on anatomical area affected identified on gross visual assessment. We have sought to understand if it is feasible and advantageous to use left ventricular global longitudinal strain (LVGLS), LV segmental longitudinal strain and right ventricle free wall strain (RVFWS) to classify TTC.
520			_aCONCLUSIONS: A new classification of TCC based on strain analysis should be developed. The traditional model is arbitrary; it fails to recognize that in most patients the entire LV is affect, it does not have prognostic significance and the most prevalent typical variant indicates apical involvement. Our study suggests that the entire LV is affected, and strain analysis has prognostic significance.
520			_aMETHODS: We conducted a retrospective observational study on twenty-five patients who meet the Modified Mayo Clinic Criteria for TTC [1]. Two independent reviewers performed strain analysis, they were both blinded to patient's diagnosed classification and outcomes.
520			_aRESULTS: Based on classification by traditional assessment the 92% (n=23) were diagnosed with typical TTC, indicating apical involvement. The entire LV was affected, 67% (n=16) had abnormal strain (STE>-18) in all three LV regions (base, mid ventricle and apex). 71% of patients (n=17) had abnormal LVGLS (>-18). Abnormal strain across all three LV regions was associated with higher prevalence (70%, n=8 Vs 30%, n=4 respectively) of composite cardiovascular events and longer length of hospital stay. There was a statistically significant difference in average length of hospital stay in those patients who had abnormal strain in all three region compared to those that did not have abnormal strain across all three regions (8 days compared to 3.44 days, p value 0.02).
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aAsch, Federico M
700			_aForrestal, Brian John
700			_aGarcia-Garcia, Hector M
700			_aMedvedofsky, Diego
700			_aReddin, Gemma
700			_aSingh, Manavotam
790			_aAsch FM, Campos CM, Forrestal BJ, Garcia-Garcia HM, Medvedofsky D, Reddin G, Ribeiro HB, Singh M
856			_uhttps://dx.doi.org/10.23736/S0026-4725.20.05386-4 _zhttps://dx.doi.org/10.23736/S0026-4725.20.05386-4
942			_cART _dArticle
999			_c6059 _d6059