000			03200nam a22003737a 4500
008			210217s20202020 xxu||||| |||| 00| 0 eng d
022			_a2155-384X
024			_a01720094-202012000-00020 [pii]
024			_a10.14309/ctg.0000000000000283 [doi]
024			_aPMC7743841 [pmc]
040			_aOvid MEDLINE(R)
099			_a33464001
245			_aAssessment of Weight Loss and Gastrointestinal Symptoms Suggestive of Exocrine Pancreatic Dysfunction After Acute Pancreatitis.
251			_aClinical and Translational Gastroenterology. 11(12):e00283, 2020 Dec 15.
252			_aClin Transl Gastroenterol. 11(12):e00283, 2020 Dec 15.
253			_aClinical and translational gastroenterology
260			_c2020
260			_fFY2021
265			_sepublish
266			_d2021-02-17
520			_aDISCUSSION: Weight loss after AP occurs in one-quarter of patients and is associated with AP severity. EPD incidence after AP is likely underappreciated. Further work is needed to assess EPD and potential for pancreatic enzyme supplementation. Copyright (c) 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
520			_aINTRODUCTION: Studies evaluating the natural history of exocrine pancreatic dysfunction (EPD) after acute pancreatitis (AP) are sparse. This study aims to assess incidence and predictors of weight loss and gastrointestinal (GI) symptoms suggestive of EPD 12 months after an AP episode.
520			_aMETHODS: Patients enrolled in the Pancreatitis-associated Risk of Organ Failure Study at the time of an AP episode were included. Weight and GI symptom data were prospectively collected by self-report at enrollment and at 3- and 12-month (windows 2-7 and 8-20) telephone follow-ups. Multivariable logistic regression was used to assess factors associated with >=10% total body weight loss (EPD surrogate) at 12 months. A generalized estimating equation was used to measure each factor's population effect (in pounds) over 12 months after AP.
520			_aRESULTS: Follow-up at 12 months in 186 patients (median age = 54 years, 46% men, 45% biliary, 65% first AP attack) revealed weight loss >=10% from baseline, occurring in 44 patients (24%). Risk of weight loss increased with higher baseline body mass index, previous diagnosis of diabetes mellitus, and worsening AP severity (all P < 0.010). GI symptoms were reported in 13/31 (42%) patients at 12 months. AP severity was independently associated with >=10% weight loss at 12 months. Over 12 months, men lost more weight than women (average 9.5 lbs); patients with severe AP lost, on average, 14 lbs.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Washington Hospital Center
656			_aMedicine/General Internal Medicine
657			_aJournal Article
700			_aPothoulakis, Ioannis
790			_aGreer PJ, Harb D, Komara N, Koutroumpakis F, Lahooti A, Mays M, Ooka K, Papachristou GI, Paragomi P, Phillips AE, Pothoulakis I, Stello K, Whitcomb DC
856			_uhttps://dx.doi.org/10.14309/ctg.0000000000000283 _zhttps://dx.doi.org/10.14309/ctg.0000000000000283
942			_cART _dArticle
999			_c6090 _d6090