000 03542nam a22005057a 4500
008 210217s20212021 xxu||||| |||| 00| 0 eng d
022 _a0090-3493
024 _a00003246-202102000-00002 [pii]
024 _a10.1097/CCM.0000000000004783 [doi]
040 _aOvid MEDLINE(R)
099 _a33438970
245 _aNosocomial Infection. [Review]
251 _aCritical Care Medicine. 49(2):169-187, 2021 02 01.
252 _aCrit Care Med. 49(2):169-187, 2021 02 01.
252 _zCrit Care Med. 49(2):169-187, 2021 Feb 01.
253 _aCritical care medicine
260 _c2021
260 _fFY2021
265 _sppublish
266 _d2021-02-17
268 _aCritical Care Medicine. 49(2):169-187, 2021 Feb 01.
501 _aAvailable online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520 _aCONCLUSIONS: Nosocomial infections are an important determinant of outcome for patients in the ICU setting. Systematic research aimed at improving the prevention and treatment of nosocomial infections is still needed. Copyright (c) 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
520 _aDATA EXTRACTION AND DATA SYNTHESIS: Nosocomial infections in the ICU setting are evolving in multiple domains including etiologic pathogens plus novel or emerging pathogens, prevalence, host risk factors, antimicrobial resistance, interactions of the host microbiome with nosocomial infection occurrence, and understanding of pathogenesis and prevention strategies. Increasing virulence and antimicrobial resistance of nosocomial infections mandate increasing efforts toward their prevention.
520 _aDATA SOURCES AND STUDY SELECTION: We searched PubMed and OVID for peer-reviewed literature dealing with nosocomial infections in the critically ill, as well as the websites of government agencies involved with the reporting and prevention of nosocomial infections. Search terms included nosocomial infection, antibiotic resistance, microbiome, antibiotics, and intensive care.
520 _aOBJECTIVE: The first 70 years of critical care can be considered a period of "industrial revolution-like" advancement in terms of progressing the understanding and care of critical illness. Unfortunately, like the industrial revolution's impact on the environment, advancing ICU care of increasingly elderly, immunosuppressed, and debilitated individuals has resulted in a greater overall burden and complexity of nosocomial infections within modern ICUs. Given the rapid evolution of nosocomial infections, the authors provide an updated review.
546 _aEnglish
650 _a*Critical Care/og [Organization & Administration]
650 _a*Critical Illness/th [Therapy]
650 _a*Cross Infection/th [Therapy]
650 _a*Drug Resistance, Bacterial
650 _aAnti-Infective Agents, Local/tu [Therapeutic Use]
650 _aCross Infection/pc [Prevention & Control]
650 _aHumans
650 _aIntensive Care Units/og [Organization & Administration]
650 _aRisk Assessment
650 _aRisk Factors
651 _aMedStar Washington Hospital Center
656 _aMedicine/Pulmonary-Critical Care
657 _aJournal Article
700 _aShorr, Andrew F
790 _aKollef MH, Martin-Loeches I, Micek ST, Shorr AF, Torres A
856 _uhttps://dx.doi.org/10.1097/CCM.0000000000004783
_zhttps://dx.doi.org/10.1097/CCM.0000000000004783
942 _cART
_dArticle
999 _c6114
_d6114