000			04508nam a22004217a 4500
008			210607s20212021 xxu||||| |||| 00| 0 eng d
022			_a1359-4184
024			_a10.1038/s41380-021-01087-0 [doi]
024			_a10.1038/s41380-021-01087-0 [pii]
040			_aOvid MEDLINE(R)
099			_a33859359
245			_aMulti-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
251			_aMolecular Psychiatry. 26(11):6293-6304, 2021 11.
252			_aMol Psychiatry. 26(11):6293-6304, 2021 11.
252			_zMol Psychiatry. 2021 Apr 15
253			_aMolecular psychiatry
260			_c2021
260			_fFY2021
265			_sppublish
266			_d2021-06-07
268			_aMolecular Psychiatry. 2021 Apr 15
520			_aLong and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 Pjoint < 5 x 10-8), including rs7955964 (FIGNL2/ANKRD33) that increases BP among long sleepers, and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) that increase BP among short sleepers (Pint < 5 x 10-8). Secondary ancestry-specific analysis identified another novel gene by long sleep interaction at rs111887471 (TRPC3/KIAA1109) in individuals of African ancestry (Pint = 2 x 10-6). Combined stage 1 and 2 analyses additionally identified significant gene by long sleep interactions at 10 loci including MKLN1 and RGL3/ELAVL3 previously associated with BP, and significant gene by short sleep interactions at 10 loci including C2orf43 previously associated with BP (Pint < 10-3). 2df test also identified novel loci for BP after modeling sleep that has known functions in sleep-wake regulation, nervous and cardiometabolic systems. This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.
546			_aEnglish
650			_a*Genome-Wide Association Study
650			_a*Hypertension
650			_aBlood Pressure/ge [Genetics]
650			_aGenetic Loci/ge [Genetics]
650			_aHumans
650			_aHypertension/ge [Genetics]
650			_aPolymorphism, Single Nucleotide/ge [Genetics]
650			_aSleep/ge [Genetics]
651			_aMedStar Heart & Vascular Institutena
657			_aJournal Article
700			_aBarac, Ana
790			_aAlver M, Amin N, Arking DE, Aschard H, Barac A, Bartz TM, Bentley AR, Biermasz NR, Bis JC, Boerwinkle E, Bouchard C, Brown MR, Cade BE, Chen H, Chen YI, Chitrala K, de Vries PS, Deary IJ, Dorr M, Eiriksdottir G, Esko T, Evans MK, Fornage M, Fox ER, Franceschini N, Gao C, Gauderman WJ, Gharib SA, Gieger C, Gottlieb DJ, Grabe HJ, Gudnason V, Guo X, Hall KA, Harris SE, He J, Heikkinen S, Hillman DR, Horimoto AR, Ikram MA, Ilkov M, Kahonen M, Kelly TN, Kilpelainen TO, Komulainen P, Kooperberg C, Krieger JE, Kuhnel B, Lakka TA, Launer LJ, Lee J, Lehtimaki T, Levy D, Lim E, Liu CT, Liu Y, Lohman KK, Luik AI, Lyytikainen LP, Magi R, Manning AK, Martin LW, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mook-Kanamori DO, Morrison AC, Mukherjee S, Munroe PB, Musani SK, Nierenberg JL, Nolte IM, Noordam R, North KE, O'Connell J, Palmas W, Palmer LJ, Palmer ND, Penninx BWJH, Pereira AC, Peters A, Psaty BM, Rankinen T, Rao DC, Rauramaa R, Redline S, Rice K, Rice TK, Rich SS, Richard M, Roenneberg T, Rotter JI, Schreiner PJ, Schwander K, Shikany JM, Shu XO, Sidney S, Sims M, Snieder H, Sofer T, Starr JM, Strauch K, Sung YJ, Uitterlinden AG, van der Most PJ, van Duijn CM, van Heemst D, Vojinovic D, Volker U, Wagenknecht LE, Waken RJ, Waldenberger M, Wallace RB, Wang H, Weiss S, Wen W, Wilson G, Winkler TW, Xu H, Yao J, Zee PC, Zheng W, Zhu X, Zonderman AB
856			_uhttps://dx.doi.org/10.1038/s41380-021-01087-0 _zhttps://dx.doi.org/10.1038/s41380-021-01087-0
942			_cART _dArticle
999			_c6310 _d6310