| 000 | 02384nam a22003737a 4500 | ||
|---|---|---|---|
| 008 | 210628s20212021 xxu||||| |||| 00| 0 eng d | ||
| 022 | _a2211-0348 | ||
| 024 | _a10.1016/j.msard.2021.103011 [doi] | ||
| 024 | _aS2211-0348(21)00278-9 [pii] | ||
| 040 | _aOvid MEDLINE(R) | ||
| 099 | _a34015641 | ||
| 245 | _aConus involvement and leptomeningeal enhancement in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: A case report. | ||
| 251 | _aMultiple Sclerosis and Related Disorders. 52:103011, 2021 May 07. | ||
| 252 | _aMult Scler Relat Disord. 52:103011, 2021 May 07. | ||
| 253 | _aMultiple sclerosis and related disorders | ||
| 260 | _c2021 | ||
| 260 | _fFY2021 | ||
| 260 | _p2021 May 07 | ||
| 265 | _saheadofprint | ||
| 266 | _d2021-06-28 | ||
| 520 | _aThere are a variety of clinical phenotypes and radiological features that continue to make a diagnosis of neuromyelitis optica spectrum disorder (NMOSD) challenging. We present an atypical case of an adult woman who presented with flaccid paralysis of all extremities with unusual neuroimaging features, including extensive enhancing lesions in the upper cervical cord and conus medullaris with associated leptomeningeal enhancement. She was ultimately found to have AQP4 antibody-positive NMOSD. We discuss the factors that complicated a timely diagnosis, including her atypical radiographic features and an initially negative cell-based assay for myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies. Despite the rarity of conus medullaris involvement or leptomeningeal enhancement in AQP4 antibody-positive NMOSD, it is important to maintain a high level of clinical suspicion to avoid diagnostic and therapeutic delays. Though cell-based assays have high sensitivities, testing should be repeated on negative values in these scenarios. Copyright (c) 2021 Elsevier B.V. All rights reserved. | ||
| 546 | _aEnglish | ||
| 650 | _aIN PROCESS -- NOT YET INDEXED | ||
| 651 | _aMedStar Washington Hospital Center | ||
| 656 | _aNeurology | ||
| 656 | _aNeurology Residency | ||
| 657 | _aLetter | ||
| 700 | _aHu, Nancy | ||
| 700 | _aMyers, Cory | ||
| 700 | _aSafadi, Amy | ||
| 790 | _aHu NN, Myers CJ, Osborne B, Safadi AL | ||
| 856 |
_uhttps://dx.doi.org/10.1016/j.msard.2021.103011 _zhttps://dx.doi.org/10.1016/j.msard.2021.103011 |
||
| 942 |
_cART _dArticle |
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| 999 |
_c6417 _d6417 |
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