000			03790nam a22006257a 4500
008			210719s20212021 xxu||||| |||| 00| 0 eng d
022			_a0196-0709
024			_a10.1016/j.amjoto.2021.102963 [doi]
024			_aS0196-0709(21)00064-8 [pii]
040			_aOvid MEDLINE(R)
099			_a33706120
245			_aRole of tonsillectomy and adenoidectomy in parental satisfaction of treatments for PANDAS.
251			_aAmerican Journal of Otolaryngology. 42(4):102963, 2021 Jul-Aug.
252			_aAm J Otolaryngol. 42(4):102963, 2021 Jul-Aug.
252			_zAm J Otolaryngol. 42(4):102963, 2021 Jul-Aug.
253			_aAmerican journal of otolaryngology
260			_c2021
260			_fFY2022
260			_p2021 Jul-Aug
265			_sppublish
266			_d2021-07-19
268			_aAmerican Journal of Otolaryngology. 42(4):102963, 2021 Jul-Aug.
269			_fFY2022
520			_aCONCLUSION: Caregivers reported a decreasing frequency of symptoms over time regardless of treatment and had no difference in satisfaction. T&A was the most preferred treatment and the most impactful on symptoms for surgical patients. Given the challenges of immunologic therapies, T&A in combination with antibiotics should be considered as an early intervention for PANDAS. Copyright (c) 2021. Published by Elsevier Inc.
520			_aMETHODS: A list was created for PANDAS subjects seen at the Georgetown Pediatric Otolaryngology clinic from 2015 to 2018. Questionnaires were distributed to caregivers able to be contacted; 62% responded (n = 60). Subjects were placed in groups based on treatments reported: tonsillectomy and adenoidectomy (T&A, n = 28), T&A and intravenous immunoglobulin (IVIG, n = 22), or nonsurgical treatment(s) (n = 10). Caregivers reported frequencies for each of 10 associated symptoms from time of treatment to 12 months and also expressed their satisfaction with treatment.
520			_aOBJECTIVE: To examine caregiver satisfaction with treatments for pediatric autoimmune neuropsychiatric disorder associated with streptococcus (PANDAS) and how symptom frequency changes over time.
520			_aRESULTS: Patients were treated with antibiotics (n = 60, 100%), T&A (83.3%), IVIG (40%), Rituximab (15%), steroids (20%), and/or plasma exchange (10%). Caregivers for 66% (n = 33) of surgical patients identified T&A as the most effective treatment, and 80% would choose the operation again. No difference in median caregiver satisfaction level was found among the groups (n = 0.196). There was no significant difference in frequency for any of the symptoms (all p > 0.05) except choreiform movement (p = 0.0296).
546			_aEnglish
650			_a*Adenoidectomy
650			_a*Autoimmune Diseases/su [Surgery]
650			_a*Caregivers/px [Psychology]
650			_a*Parents/px [Psychology]
650			_a*Personal Satisfaction
650			_a*Streptococcal Infections/su [Surgery]
650			_a*Tonsillectomy
650			_aAdolescent
650			_aAdult
650			_aAnti-Bacterial Agents/tu [Therapeutic Use]
650			_aAutoimmune Diseases/co [Complications]
650			_aChild
650			_aChild, Preschool
650			_aCombined Modality Therapy
650			_aHumans
650			_aImmunoglobulins, Intravenous/tu [Therapeutic Use]
650			_aMiddle Aged
650			_aStreptococcal Infections/co [Complications]
650			_aTime Factors
651			_aMedStar Washington Hospital Center
656			_aPsychiatry Residency
657			_aJournal Article
700			_aPowell, Daniel
790			_aHarley E, Johng S, Latimer E, Powell D, Prasad N, Williams M
856			_uhttps://dx.doi.org/10.1016/j.amjoto.2021.102963 _zhttps://dx.doi.org/10.1016/j.amjoto.2021.102963
942			_cART _dArticle
999			_c6632 _d6632