000			03668nam a22005297a 4500
008			210726s20212021 xxu||||| |||| 00| 0 eng d
024			_a10.5152/balkanmedj.2021.21187 [doi]
040			_aOvid MEDLINE(R)
099			_a34274913
245			_aSingle Institutional Experience on Orbital Inflammatory Pseudotumor: Diagnostic and Management Challenge.
251			_aBalkan Medical Journal. 38(4):239-243, 2021 07.
252			_aBalkan Med. J.. 38(4):239-243, 2021 07.
252			_zBalkan Med. J.. 38(4):239-243, 2021 Jul.
253			_aBalkan medical journal
260			_c2021
260			_fFY2022
260			_p2021 Jul
265			_sppublish
266			_d2021-07-26
268			_aBalkan Medical Journal. 38(4):239-243, 2021 Jul.
269			_fFY2022
520			_aAIMS: Orbital inflammatory pseudotumor is considered a non-neoplastic inflammatory process. The finding of clonality of B or T-cell receptors in cases pathologically diagnosed as orbital inflammatory pseudotumor has unknown clinicopathologic significance. We sought to investigate potential B and T-cell clonality and concomitant diseases in cases pathologically diagnosed as orbital inflammatory pseudotumor.
520			_aCONCLUSION: A small but significant percentage of typical orbital inflammatory pseudotumor on histology showed B-cell clonality on polymerase chain reactions analysis of B-cell receptors, or features suggestive, but not diagnostic of IgG4-RD. Close follow-up of these patients to identify development of lymphoma, systemic IgG4-RD, or other rheumatologic conditions may be clinically warranted.
520			_aMETHODS: Cases diagnosed as orbital inflammatory pseudotumor at our institution were retrospectively analyzed. Hematoxylin and eosinstained slides, immunohistochemically stained slides and polymerase chain reactions on cell block material for the investigation of clonality of B and T-cell receptors were evaluated, to confirm the diagnosis and investigate the prevalence of concomitant diseases.
520			_aRESULTS: A total of 13 cases showing characteristic histopathologic features of orbital inflammatory pseudotumor were identified. CD138, IgG, and IgG4 showed varying numbers of plasma cells in each case, with 5 cases (5/13, 38%) exhibiting relative increase in the presence of IgG4 plasma cells. However, no cases showed diagnostic findings of IgG4-related disease (IgG4-RD). polymerase chain reactions analysis showed clonal B-cell populations in 2 cases (2/13, 15%). No cases showed anaplastic lymphoma kinase expression by immunohistochemistry. There were no clinical reports of progression to lymphoma or development of systemic IgG4-RD in any of the patients (average follow-up of 300 days), with 38% of patients showing systemic autoimmune conditions.
546			_aEnglish
650			_a*Orbital Pseudotumor/di [Diagnosis]
650			_a*Orbital Pseudotumor/th [Therapy]
650			_aAdult
650			_aAged
650			_aFemale
650			_aHumans
650			_aImmunoglobulin G/an [Analysis]
650			_aMale
650			_aMiddle Aged
650			_aOrbital Pseudotumor/pa [Pathology]
650			_aRetrospective Studies
650			_aSyndecan-1/an [Analysis]
651			_aMedStar Washington Hospital Center
656			_aPathology Residency
657			_aJournal Article
700			_aDerakhshandeh, Roshanak
700			_aDimopoulos, Yiannis Petros
790			_aChanine J, Derakhshandeh R, Dimopoulos YP, Goodglick TA, Ozdemirli M, Sabet S
856			_uhttps://dx.doi.org/10.5152/balkanmedj.2021.21187 _zhttps://dx.doi.org/10.5152/balkanmedj.2021.21187
942			_cART _dArticle
999			_c6698 _d6698