000			03762nam a22005057a 4500
008			220222s20222022 xxu||||| |||| 00| 0 eng d
024			_a10.1016/j.jacc.2021.11.042 [doi]
024			_aS0735-1097(21)08318-2 [pii]
040			_aOvid MEDLINE(R)
099			_a35144744
245			_aDiscordance Between Standard Equations for Determination of LDL Cholesterol in Patients With Atherosclerosis.
251			_aJournal of the American College of Cardiology. 79(6):530-541, 2022 02 15.
252			_aJ Am Coll Cardiol. 79(6):530-541, 2022 02 15.
252			_zJ Am Coll Cardiol. 79(6):530-541, 2022 02 15.
253			_aJournal of the American College of Cardiology
260			_c2022
260			_fFY2022
260			_p2022 02 15
265			_sppublish
266			_d2022-02-22
268			_aJournal of the American College of Cardiology. 79(6):530-541, 2022 02 15.
501			_aAvailable online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
520			_aBACKGROUND: Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is important for guiding cholesterol-lowering therapy. Different methods currently exist to estimate LDL-C.
520			_aCONCLUSIONS: Clinically meaningful differences in estimated LDL-C exist among equations, particularly at TG levels of >=150 mg/dL and/or lower LDL-C levels. Reliance on the Friedewald and Sampson equations may result in the underestimation and undertreatment of LDL-C in those at increased risk. Copyright (c) 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
520			_aMETHODS: Electronic health record data from patients with atherosclerotic cardiovascular disease and triglyceride (TG) levels of <400 mg/dL between October 1, 2015, and June 30, 2019, were retrospectively analyzed. LDL-C was estimated using the Friedewald, Sampson, and Martin/Hopkins equations. Patients were categorized as concordant if LDL-C was <70 mg/dL with each pairwise comparison of equations and as discordant if LDL-C was <70 mg/dL for the index equation and >=70 mg/dL for the comparator.
520			_aOBJECTIVES: This study sought to assess discordance of estimated LDL-C using the Friedewald, Sampson, and Martin/Hopkins equations.
520			_aRESULTS: The study included 146,106 patients with atherosclerotic cardiovascular disease (mean age: 68 years; 56% male; 91% White). The Martin/Hopkins equation consistently estimated higher LDL-C values than the Friedewald and Sampson equations. Discordance rates were 15% for the Friedewald vs Martin/Hopkins comparison, 9% for the Friedewald vs Sampson comparison, and 7% for the Sampson vs Martin/Hopkins comparison. Discordance increased at lower LDL-C cutpoints and in those with elevated TG levels. Among patients with TG levels of >=150 mg/dL, a >10 mg/dL difference in LDL-C was present in 67%, 27%, and 23% of patients when comparing the Friedewald vs Martin/Hopkins, Friedewald vs Sampson, and Sampson vs Martin/Hopkins equations, respectively.
546			_aEnglish
650			_a*Atherosclerosis/bl [Blood]
650			_a*Cholesterol, LDL/bl [Blood]
650			_aAged
650			_aBiomarkers/bl [Blood]
650			_aFemale
650			_aHumans
650			_aMale
650			_aRetrospective Studies
650			_aTriglycerides/bl [Blood]
651			_aMedStar Washington Hospital Center
656			_aCardiovascular Disease Fellowship
657			_aJournal Article
700			_aSajja, Aparna
790			_aBlumenthal RS, Gluckman TJ, Li HF, Martin SS, Sajja A, Spinelli KJ, Virani SS
856			_uhttps://dx.doi.org/10.1016/j.jacc.2021.11.042 _zhttps://dx.doi.org/10.1016/j.jacc.2021.11.042
942			_cART _dArticle
999			_c776 _d776