Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis.
Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis.
- 2020
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
CONCLUSION: This study provides novel insights into the putative role of WM tract abnormalities in the pathogenesis of PD-P by demonstrating significant alterations in several WM tracts. Additional longitudinal studies are warranted to confirm the findings of our research. Copyright (c) 2020 American Academy of Neurology. METHODS: This cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. A set of neuropsychological tests was used for the cognitive evaluation of all patients. OBJECTIVE: The objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI). RESULTS: The severity and stage of PD were not statistically different between the groups. The PD-P group performed poorly in all the neuropsychological domains compared with the PD-NP group. TBSS analysis revealed widespread patterns of abnormality in the fractional anisotropy (FA) in the PD-P group, which also correlated with some of the cognitive scores. These tracts include inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, right parieto-occipital WM, body of the corpus callosum, and corticospinal tract.
English
0028-3878
10.1212/WNL.0000000000009363 [doi] WNL.0000000000009363 [pii]
*Brain/pa [Pathology]
*Parkinson Disease/pa [Pathology]
*Psychotic Disorders/pa [Pathology]
*White Matter/pa [Pathology]
Aged
Cross-Sectional Studies
Diffusion Tensor Imaging
Female
Humans
Male
Middle Aged
Parkinson Disease/co [Complications]
Psychotic Disorders/et [Etiology]
MedStar Washington Hospital Center
Neurology
Comment
Journal Article
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
CONCLUSION: This study provides novel insights into the putative role of WM tract abnormalities in the pathogenesis of PD-P by demonstrating significant alterations in several WM tracts. Additional longitudinal studies are warranted to confirm the findings of our research. Copyright (c) 2020 American Academy of Neurology. METHODS: This cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. A set of neuropsychological tests was used for the cognitive evaluation of all patients. OBJECTIVE: The objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI). RESULTS: The severity and stage of PD were not statistically different between the groups. The PD-P group performed poorly in all the neuropsychological domains compared with the PD-NP group. TBSS analysis revealed widespread patterns of abnormality in the fractional anisotropy (FA) in the PD-P group, which also correlated with some of the cognitive scores. These tracts include inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, right parieto-occipital WM, body of the corpus callosum, and corticospinal tract.
English
0028-3878
10.1212/WNL.0000000000009363 [doi] WNL.0000000000009363 [pii]
*Brain/pa [Pathology]
*Parkinson Disease/pa [Pathology]
*Psychotic Disorders/pa [Pathology]
*White Matter/pa [Pathology]
Aged
Cross-Sectional Studies
Diffusion Tensor Imaging
Female
Humans
Male
Middle Aged
Parkinson Disease/co [Complications]
Psychotic Disorders/et [Etiology]
MedStar Washington Hospital Center
Neurology
Comment
Journal Article