Impact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis.
Impact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis.
- 2024
BACKGROUND: Although anemia is common in patients with myocardial infarction (MI), management remains controversial. We quantified the association of anemia with in-hospital outcomes and resource utilization in patients admitted with MI using a large national database. CONCLUSION: In MI patients, anemia was associated with higher in-hospital mortality, adverse events, total cost, and length of stay. Transfusion was associated with increased mortality, and its role in MI requires further research. Copyright © 2023. Published by Elsevier B.V. METHODS: All hospitalizations with a primary diagnosis code for acute MI in the National Inpatient Sample (NIS) between 2014 and 2018 were identified. Among these hospitalizations, patients with anemia were identified using a secondary diagnosis code. Data on demographic and clinical variables were collected. Outcomes of interest included in-hospital adverse events, length of stay (LOS), and total cost. Multivariable logistic regression and generalized linear models were used to evaluate the relationship between anemia and outcomes. RESULTS: Among 1,113,181 MI hospitalizations, 254,816 (22.8%) included concomitant anemia. Anemic patients were older and more likely to be women. After adjustment for demographics and comorbidities, anemia was associated with higher mortality (7.1 vs. 4.3%; odds ratio 1.09; 95% confidence interval [CI] 1.07-1.12, p < 0.001). Anemia was also associated with a mean of 2.71 days longer LOS (average marginal effects [AME] 2.71; 95% CI 2.68-2.73, p < 0.05), and
English
0167-5273
S0167-5273(24)00733-2 [pii]
*Anemia
*Databases, Factual
*Myocardial Infarction
Aged
Aged, 80 and over
Anemia/ec [Economics]
Anemia/ep [Epidemiology]
Anemia/th [Therapy]
Female
Health Resources/ec [Economics]
Health Resources/sn [Statistics & Numerical Data]
Hospital Mortality/td [Trends]
Hospitalization/ec [Economics]
Hospitalization/sn [Statistics & Numerical Data]
Humans
Length of Stay/sn [Statistics & Numerical Data]
Male
Middle Aged
Myocardial Infarction/co [Complications]
Myocardial Infarction/ec [Economics]
Myocardial Infarction/ep [Epidemiology]
Myocardial Infarction/th [Therapy]
Retrospective Studies
United States/ep [Epidemiology]--Automated
MedStar Washington Hospital Center
Advanced Cardiac Catheterization Research Fellowship
Journal Article
BACKGROUND: Although anemia is common in patients with myocardial infarction (MI), management remains controversial. We quantified the association of anemia with in-hospital outcomes and resource utilization in patients admitted with MI using a large national database. CONCLUSION: In MI patients, anemia was associated with higher in-hospital mortality, adverse events, total cost, and length of stay. Transfusion was associated with increased mortality, and its role in MI requires further research. Copyright © 2023. Published by Elsevier B.V. METHODS: All hospitalizations with a primary diagnosis code for acute MI in the National Inpatient Sample (NIS) between 2014 and 2018 were identified. Among these hospitalizations, patients with anemia were identified using a secondary diagnosis code. Data on demographic and clinical variables were collected. Outcomes of interest included in-hospital adverse events, length of stay (LOS), and total cost. Multivariable logistic regression and generalized linear models were used to evaluate the relationship between anemia and outcomes. RESULTS: Among 1,113,181 MI hospitalizations, 254,816 (22.8%) included concomitant anemia. Anemic patients were older and more likely to be women. After adjustment for demographics and comorbidities, anemia was associated with higher mortality (7.1 vs. 4.3%; odds ratio 1.09; 95% confidence interval [CI] 1.07-1.12, p < 0.001). Anemia was also associated with a mean of 2.71 days longer LOS (average marginal effects [AME] 2.71; 95% CI 2.68-2.73, p < 0.05), and
English
0167-5273
S0167-5273(24)00733-2 [pii]
*Anemia
*Databases, Factual
*Myocardial Infarction
Aged
Aged, 80 and over
Anemia/ec [Economics]
Anemia/ep [Epidemiology]
Anemia/th [Therapy]
Female
Health Resources/ec [Economics]
Health Resources/sn [Statistics & Numerical Data]
Hospital Mortality/td [Trends]
Hospitalization/ec [Economics]
Hospitalization/sn [Statistics & Numerical Data]
Humans
Length of Stay/sn [Statistics & Numerical Data]
Male
Middle Aged
Myocardial Infarction/co [Complications]
Myocardial Infarction/ec [Economics]
Myocardial Infarction/ep [Epidemiology]
Myocardial Infarction/th [Therapy]
Retrospective Studies
United States/ep [Epidemiology]--Automated
MedStar Washington Hospital Center
Advanced Cardiac Catheterization Research Fellowship
Journal Article