The Role of Immunotherapy in Pancreatic Cancer. [Review]
The Role of Immunotherapy in Pancreatic Cancer. [Review]
- 2022
Available online through MWHC library: 2006 - present
Pancreatic adenocarcinoma remains one of the most lethal cancers globally, with a significant need for improved therapeutic options. While the recent breakthroughs of immunotherapy through checkpoint inhibitors have dramatically changed treatment paradigms in other malignancies based on considerable survival benefits, this is not so for pancreatic cancer. Chemotherapies with modest benefits are still the cornerstone of advanced pancreatic cancer treatment. Pancreatic cancers are inherently immune-cold tumors and have been largely refractory to immunotherapies in clinical trials. Understanding and overcoming the current failures of immunotherapy through elucidating resistance mechanisms and developing novel therapeutic approaches are essential to harnessing the potential durable benefits of immune-modulating therapy in pancreatic cancer patients.
English
1198-0052
10.3390/curroncol29100541 [doi] curroncol29100541 [pii] PMC9600738 [pmc]
*Adenocarcinoma
*Pancreatic Neoplasms
Humans
Immunologic Factors
Immunotherapy
Pancreatic Neoplasms/dt [Drug Therapy]
Pancreatic Neoplasms/pa [Pathology]
MedStar Washington Hospital Center
Internal Medicine Residency
Journal Article
Review
Available online through MWHC library: 2006 - present
Pancreatic adenocarcinoma remains one of the most lethal cancers globally, with a significant need for improved therapeutic options. While the recent breakthroughs of immunotherapy through checkpoint inhibitors have dramatically changed treatment paradigms in other malignancies based on considerable survival benefits, this is not so for pancreatic cancer. Chemotherapies with modest benefits are still the cornerstone of advanced pancreatic cancer treatment. Pancreatic cancers are inherently immune-cold tumors and have been largely refractory to immunotherapies in clinical trials. Understanding and overcoming the current failures of immunotherapy through elucidating resistance mechanisms and developing novel therapeutic approaches are essential to harnessing the potential durable benefits of immune-modulating therapy in pancreatic cancer patients.
English
1198-0052
10.3390/curroncol29100541 [doi] curroncol29100541 [pii] PMC9600738 [pmc]
*Adenocarcinoma
*Pancreatic Neoplasms
Humans
Immunologic Factors
Immunotherapy
Pancreatic Neoplasms/dt [Drug Therapy]
Pancreatic Neoplasms/pa [Pathology]
MedStar Washington Hospital Center
Internal Medicine Residency
Journal Article
Review