The Role of Immunotherapy in Pancreatic Cancer. [Review]

The Role of Immunotherapy in Pancreatic Cancer. [Review] - 2022

Available online through MWHC library: 2006 - present

Pancreatic adenocarcinoma remains one of the most lethal cancers globally, with a significant need for improved therapeutic options. While the recent breakthroughs of immunotherapy through checkpoint inhibitors have dramatically changed treatment paradigms in other malignancies based on considerable survival benefits, this is not so for pancreatic cancer. Chemotherapies with modest benefits are still the cornerstone of advanced pancreatic cancer treatment. Pancreatic cancers are inherently immune-cold tumors and have been largely refractory to immunotherapies in clinical trials. Understanding and overcoming the current failures of immunotherapy through elucidating resistance mechanisms and developing novel therapeutic approaches are essential to harnessing the potential durable benefits of immune-modulating therapy in pancreatic cancer patients.


English

1198-0052

10.3390/curroncol29100541 [doi] curroncol29100541 [pii] PMC9600738 [pmc]


*Adenocarcinoma
*Pancreatic Neoplasms
Humans
Immunologic Factors
Immunotherapy
Pancreatic Neoplasms/dt [Drug Therapy]
Pancreatic Neoplasms/pa [Pathology]


MedStar Washington Hospital Center


Internal Medicine Residency


Journal Article
Review

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