Brief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers.

Brief topical sodium nitrite and its impact on the quality of life in patients with sickle leg ulcers. - 2018

Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006

Cutaneous ulceration from sickle cell disease negatively impacts quality of life. Topical sodium nitrite has previously been shown to reduce the size of sickle leg ulcers. This study examined how topical sodium nitrite impacted the quality of life scores in patients with sickle leg ulcers.We prospectively collected data in patients enrolled in a leg ulcer study (n = 17) or an allogeneic hematopoietic cell transplant study (nonulcer group, n = 15). Both groups completed a pretreatment Short Form-36 questionnaire; the ulcer group completed a second questionnaire after 4 weeks of topical sodium nitrite applications. Data were analyzed by age, sex, >50% area improvement postintervention, and sickle-related complications (vaso-occlusive crises, pulmonary hypertension, or avascular necrosis). Physical and mental component summary scores were analyzed with Student t test.Physical summary scores were lower than mental summary scores in all groups, indicating leg ulcers among other sickle related complications negatively impacted physical quality of life measures. After sodium nitrite use, physical summary scores improved in the leg ulcer group (34.5 +/- 9.4 to 39 +/- 10.3, P = .03), and mental summary scores improved more in ulcerated patients <=35 years old (40.7 +/- 6.9 to 51.7 +/- 9.7, P = .01).Brief topical sodium nitrite has the potential to improve quality of life, especially in younger individuals. Longer treatment duration and randomized-controlled trials are needed to confirm the efficacy of this topical therapy.


English

0025-7974

00005792-201811160-00002 [pii] 10.1097/MD.0000000000012614 [doi]


*Anemia, Sickle Cell/co [Complications]
*Leg Ulcer/dt [Drug Therapy]
*Patient Reported Outcome Measures
*Quality of Life
*Sodium Nitrite/ad [Administration & Dosage]
Administration, Topical
Adolescent
Adult
Female
Hematopoietic Stem Cell Transplantation
Humans
IN PROCESS -- NOT YET INDEXED
Leg Ulcer/et [Etiology]
Male
Middle Aged
Preoperative Period
Prospective Studies
Treatment Outcome
Wound Healing/de [Drug Effects]
Young Adult


MedStar National Rehabilitation Network


Clinical Trial
Journal Article

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