Garcia-Garcia, Hector M Mintz, Gary S Ozaki, Yuichi Waksman, Ron

Supporting evidence from optical coherence tomography for shortening dual antiplatelet therapy after drug-eluting stents implantation. [Review] - 2020

Introduction: Dual antiplatelet therapy (DAPT) is required for coronary artery disease treated with drug-eluting stents (DES) implantation. Shortening DAPT duration would be beneficial for patients with high bleeding risk. Areas covered: Early healing patterns, especially stent strut coverage, assessed by optical coherence tomography (OCT) as a surrogate of neointima have been investigated to make decisions on whether short DAPT would be a safe alternative. This review evaluates the OCT evidence (i.e. neointimal coverage of stent struts within 3 months) for shortening DAPT duration after DES implantation. Expert commentary: Shortening DAPT (i.e. within 3 months) duration after DES implantation might reduce complications including bleeding without increasing stent thrombosis. However, the optimal duration of DAPT after DES implantation is under discussion. Long-term assessment of short DAPT is required for the decision of the new guidelines regarding the recommended duration of DAPT.


English

1477-9072

10.1080/14779072.2020.1759421 [doi]


Coronary Artery Disease/th [Therapy]
Treatment Outcome
*Tomography, Optical Coherence/mt [Methods]
Thrombosis/et [Etiology]
*Platelet Aggregation Inhibitors/ad [Administration & Dosage]
Neointima
Humans
Hemorrhage/ci [Chemically Induced]
*Drug-Eluting Stents


MedStar Heart & Vascular Institute


Journal Article

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