Nazari, Matthew

Pathophysiology and Acute Management of Tachyarrhythmias in Pheochromocytoma: JACC Review Topic of the Week. [Review] - 2020

Pheochromocytomas, arising from chromaffin cells, produce catecholamines, epinephrine and norepinephrine. The tumor biochemical phenotype is defined by which of these exerts the greatest influence on the cardiovascular system when released into circulation in high amounts. Action on the heart and vasculature can cause potentially lethal arrhythmias, often in the setting of comorbid blood pressure derangements. In a review of electrocardiograms obtained on pheochromocytoma patients (n = 650) treated at our institution over the last decade, severe and refractory sinus tachycardia, atrial fibrillation, and ventricular tachycardia were found to be the most common or life-threatening catecholamine-induced tachyarrhythmias. These arrhythmias, arising from catecholamine excess rather than from a primary electrophysiologic substrate, require special considerations for treatment and complication avoidance. Understanding the synthesis and release of catecholamines, the adrenoceptors catecholamines bind to, and the cardiac and vascular response to epinephrine and norepinephrine underlies optimal management in catecholamine-induced tachyarrhythmias. Copyright (c) 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.



10.1016/j.jacc.2020.04.080 [doi] S0735-1097(20)35542-X [pii]

*Patient Care Management/mt [Methods]
Adrenal Gland Neoplasms/co [Complications]
Adrenal Gland Neoplasms/me [Metabolism]
Adrenal Gland Neoplasms/pa [Pathology]
Pheochromocytoma/co [Complications]
Pheochromocytoma/me [Metabolism]
Pheochromocytoma/pa [Pathology]
Tachycardia/et [Etiology]
Tachycardia/pp [Physiopathology]
Tachycardia/th [Therapy]

MedStar Washington Hospital Center

Medicine/Internal Medicine

Journal Article

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