MARC details
000 -LEADER |
fixed length control field |
03928nam a22005177a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
220124s20212021 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0149-5992 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.2337/dc21-0451 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
dc21-0451 [pii] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
PMC8669540 [pmc] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
34702783 |
245 ## - TITLE STATEMENT |
Title |
Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study. |
251 ## - Source |
Source |
Diabetes Care. 44(12):2664-2672, 2021 12. |
252 ## - Abbreviated Source |
Abbreviated source |
Diabetes Care. 44(12):2664-2672, 2021 12. |
252 ## - Abbreviated Source |
Former abbreviated source |
Diabetes Care. 44(12):2664-2672, 2021 Dec. |
253 ## - Journal Name |
Journal name |
Diabetes care |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2021 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Publication date |
2021 Dec |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
266 ## - Date added to catalog |
Date added to catalog |
2022-01-25 |
268 ## - Previous citation |
-- |
Diabetes Care. 44(12):2664-2672, 2021 Dec. |
501 ## - WITH NOTE |
Local holdings |
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006 |
520 ## - SUMMARY, ETC. |
Abstract |
CONCLUSIONS: Lipid dysregulation occurs many years preceding T2D, and novel molecular lipids (both baseline level and longitudinal change over time) are significantly associated with risk of T2D beyond traditional risk factors. Our findings shed light on the mechanisms linking dyslipidemia to T2D and may yield novel therapeutic targets for early intervention tailored to American Indians. Copyright (c) 2021 by the American Diabetes Association. |
520 ## - SUMMARY, ETC. |
Abstract |
OBJECTIVE: Comprehensive assessment of alterations in lipid species preceding type 2 diabetes (T2D) is largely unknown. We aimed to identify plasma molecular lipids associated with risk of T2D in American Indians. |
520 ## - SUMMARY, ETC. |
Abstract |
RESEARCH DESIGN AND METHODS: Using untargeted liquid chromatography-mass spectrometry, we repeatedly measured 3,907 fasting plasma samples from 1,958 participants who attended two examinations (~5.5 years apart) and were followed up to 16 years in the Strong Heart Family Study. Mixed-effects logistic regression was used to identify lipids associated with risk of T2D, adjusting for traditional risk factors. Repeated measurement analysis was performed to examine the association between change in lipidome and change in continuous measures of T2D, adjusting for baseline lipids. Multiple testing was controlled by false discovery rate at 0.05. |
520 ## - SUMMARY, ETC. |
Abstract |
RESULTS: Higher baseline level of 33 lipid species, including triacylglycerols, diacylglycerols, phosphoethanolamines, and phosphocholines, was significantly associated with increased risk of T2D (odds ratio [OR] per SD increase in log2-transformed baseline lipids 1.50-2.85) at 5-year follow-up. Of these, 21 lipids were also associated with risk of T2D at 16-year follow-up. Aberrant lipid profiles were also observed in prediabetes (OR per SD increase in log2-transformed baseline lipids 1.30-2.19 for risk lipids and 0.70-0.78 for protective lipids). Longitudinal changes in 568 lipids were significantly associated with changes in continuous measures of T2D. Multivariate analysis identified distinct lipidomic signatures differentiating high- from low-risk groups. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Diabetes Mellitus, Type 2 |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Lipidomics |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
American Indians or Alaska Natives |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Fasting |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Glucose |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Risk Factors |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Health Research Institute |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Howard, Barbara V |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Umans, Jason G |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Zhu, Jianhui |
790 ## - Authors |
All authors |
Cole SA, DeFelice B, Fiehn O, Fretts AM, Howard BV, Huo Z, Lee ET, Miao G, Pedrosa D, Umans JG, Wohlgemuth G, Zeng W, Zhang Y, Zhao J, Zhu J |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.2337/dc21-0451">https://dx.doi.org/10.2337/dc21-0451</a> |
Public note |
https://dx.doi.org/10.2337/dc21-0451 |
858 ## - ORCID |
ORCID text |
Howard, Barbara V |
Orcid |
<a href="https://orcid.org/0000-0002-4216-7859">https://orcid.org/0000-0002-4216-7859</a> |
Name |
https://orcid.org/0000-0002-4216-7859 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |