Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study. (Record no. 10939)

MARC details
000 -LEADER
fixed length control field 03928nam a22005177a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 220124s20212021 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0149-5992
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.2337/dc21-0451 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code dc21-0451 [pii]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC8669540 [pmc]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 34702783
245 ## - TITLE STATEMENT
Title Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study.
251 ## - Source
Source Diabetes Care. 44(12):2664-2672, 2021 12.
252 ## - Abbreviated Source
Abbreviated source Diabetes Care. 44(12):2664-2672, 2021 12.
252 ## - Abbreviated Source
Former abbreviated source Diabetes Care. 44(12):2664-2672, 2021 Dec.
253 ## - Journal Name
Journal name Diabetes care
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2021
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2022
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2021 Dec
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
266 ## - Date added to catalog
Date added to catalog 2022-01-25
268 ## - Previous citation
-- Diabetes Care. 44(12):2664-2672, 2021 Dec.
501 ## - WITH NOTE
Local holdings Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
520 ## - SUMMARY, ETC.
Abstract CONCLUSIONS: Lipid dysregulation occurs many years preceding T2D, and novel molecular lipids (both baseline level and longitudinal change over time) are significantly associated with risk of T2D beyond traditional risk factors. Our findings shed light on the mechanisms linking dyslipidemia to T2D and may yield novel therapeutic targets for early intervention tailored to American Indians. Copyright (c) 2021 by the American Diabetes Association.
520 ## - SUMMARY, ETC.
Abstract OBJECTIVE: Comprehensive assessment of alterations in lipid species preceding type 2 diabetes (T2D) is largely unknown. We aimed to identify plasma molecular lipids associated with risk of T2D in American Indians.
520 ## - SUMMARY, ETC.
Abstract RESEARCH DESIGN AND METHODS: Using untargeted liquid chromatography-mass spectrometry, we repeatedly measured 3,907 fasting plasma samples from 1,958 participants who attended two examinations (~5.5 years apart) and were followed up to 16 years in the Strong Heart Family Study. Mixed-effects logistic regression was used to identify lipids associated with risk of T2D, adjusting for traditional risk factors. Repeated measurement analysis was performed to examine the association between change in lipidome and change in continuous measures of T2D, adjusting for baseline lipids. Multiple testing was controlled by false discovery rate at 0.05.
520 ## - SUMMARY, ETC.
Abstract RESULTS: Higher baseline level of 33 lipid species, including triacylglycerols, diacylglycerols, phosphoethanolamines, and phosphocholines, was significantly associated with increased risk of T2D (odds ratio [OR] per SD increase in log2-transformed baseline lipids 1.50-2.85) at 5-year follow-up. Of these, 21 lipids were also associated with risk of T2D at 16-year follow-up. Aberrant lipid profiles were also observed in prediabetes (OR per SD increase in log2-transformed baseline lipids 1.30-2.19 for risk lipids and 0.70-0.78 for protective lipids). Longitudinal changes in 568 lipids were significantly associated with changes in continuous measures of T2D. Multivariate analysis identified distinct lipidomic signatures differentiating high- from low-risk groups.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Diabetes Mellitus, Type 2
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Lipidomics
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element American Indians or Alaska Natives
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Fasting
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Glucose
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Factors
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Howard, Barbara V
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Umans, Jason G
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Zhu, Jianhui
790 ## - Authors
All authors Cole SA, DeFelice B, Fiehn O, Fretts AM, Howard BV, Huo Z, Lee ET, Miao G, Pedrosa D, Umans JG, Wohlgemuth G, Zeng W, Zhang Y, Zhao J, Zhu J
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.2337/dc21-0451">https://dx.doi.org/10.2337/dc21-0451</a>
Public note https://dx.doi.org/10.2337/dc21-0451
858 ## - ORCID
ORCID text Howard, Barbara V
Orcid <a href="https://orcid.org/0000-0002-4216-7859">https://orcid.org/0000-0002-4216-7859</a>
Name https://orcid.org/0000-0002-4216-7859
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 01/25/2022   34702783 34702783 01/25/2022 01/25/2022 Journal Article

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