MARC details
| 000 -LEADER |
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| fixed length control field |
02889nam a22003137a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
170411s20162016 xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
27047721 |
| 245 ## - TITLE STATEMENT |
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| Title |
Survival in patients with non-metastatic breast cancer treated with adjuvant trastuzumab in clinical practice. |
| 251 ## - Source |
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| Source |
Springerplus. 5:395, 2016 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Springerplus. 5:395, 2016 |
| 253 ## - Journal Name |
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| Journal name |
SpringerPlus |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2016 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2016 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2017-05-24 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: OS rates estimated in this study were in range with those estimated in the B-31/N9831 trials, while RFS rates were lower. However, patients in the B-31/N9831 trials were younger and possibly had fewer comorbidities than patients in the current study; these differences were not adjusted for in the crude OS and RFS analyses. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
METHODS: Adult women initiating adjuvant trastuzumab within 1 year of breast cancer surgery were identified in the health claims database of the US Department of Defense (01/2003-12/2012). OS and RFS unadjusted rates at 4 and 6 years after the first trastuzumab treatment following the breast cancer diagnosis were estimated from Kaplan-Meier analyses. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
PURPOSE: The NSABP Trial B-31 and NCCTG Trial N9831 (B-31/N9831 trials, Romond et al. in N Engl J Med 353:1673-84, 2005. doi:10.1056/NEJMoa052122; Perez et al. in J Clin Oncol 32:3744-52, 2014. doi:10.1200/JCO.2014.55.5730) established the efficacy of adjuvant trastuzumab for patients with HER2-positive early stage breast cancer. We aimed to estimate the overall survival (OS) and relapse-free survival (RFS) of HER2-positive non-metastatic breast cancer patients treated with adjuvant trastuzumab in a clinical practice setting in the United States. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESULTS: The study sample included 3188 women followed for a median of 3.3 years after trastuzumab initiation and treated continuously with trastuzumab for a median of 12 months. The OS rates (95 % confidence intervals) at 4 and 6 years were 90.0 % (88.6-91.2) and 87.1 (85.3-88.6), respectively. The corresponding RFS rates were 75.8 % (74.0-77.5) and 72.7 (70.7-74.7), respectively. The OS and RFS rates at 6 years reported in the B-31/N9831 trials were 89.8 and 81.4 %, respectively. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
PubMed-not-MEDLINE -- Not indexed |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
Washington Cancer Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Gallagher, Christopher |
| 790 ## - Authors |
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| All authors |
Barnett B, Butts E, Gallagher CM, Gauthier-Loiselle M, Guerin A, Ionescu-Ittu R, Kamath T, Masaquel A, More K, Nitulescu R, Sicignano N, Wu EQ |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1186/s40064-016-2008-9">https://dx.doi.org/10.1186/s40064-016-2008-9</a> |
| Public note |
https://dx.doi.org/10.1186/s40064-016-2008-9 |
| 858 ## - ORCID |
|---|
| ORCID text |
Gallagher, Christopher M |
| Orcid |
<a href="ORCID: https://orcid.org/0000-0002-3846-5052">ORCID: https://orcid.org/0000-0002-3846-5052</a> |
| Name |
ORCID: https://orcid.org/0000-0002-3846-5052 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
