BRCA1/2 mutations and risk-reducing bilateral salpingo-oophorectomy among Latinas: The UPTAKE study. (Record no. 11010)

MARC details
000 -LEADER
fixed length control field 04360nam a22005657a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210607s20212021 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1059-7700
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1002/jgc4.1322 [doi]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 33010199
245 ## - TITLE STATEMENT
Title BRCA1/2 mutations and risk-reducing bilateral salpingo-oophorectomy among Latinas: The UPTAKE study.
251 ## - Source
Source Journal of Genetic Counseling. 30(2):383-393, 2021 04.
252 ## - Abbreviated Source
Abbreviated source J Genet Couns. 30(2):383-393, 2021 04.
252 ## - Abbreviated Source
Former abbreviated source J Genet Couns. 30(2):383-393, 2021 Apr.
253 ## - Journal Name
Journal name Journal of genetic counseling
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2021
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2021
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
266 ## - Date added to catalog
Date added to catalog 2020-12-29
268 ## - Previous citation
-- Journal of Genetic Counseling. 30(2):383-393, 2021 Apr.
520 ## - SUMMARY, ETC.
Abstract Bilateral salpingo-oophorectomy (BSO) is a risk management approach with strong evidence of mortality reduction for women with germline mutations in the tumor suppressor genes BRCA1 and BRCA2 (BRCA1/2). Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds who carry BRCA1/2 mutations. The objective of the UPTAKE study was to explore rates and predictors of risk-reducing BSO among Latinas affected and unaffected with breast cancer who had a deleterious BRCA1/2 mutation. We recruited 100 Latina women with deleterious BRCA1/2 mutations from community hospitals, academic health systems, community, and advocacy organizations. Women completed interviews in Spanish or English. We obtained copies of genetic test reports for participants who provided signed medical release. After performing threefold cross-validation LASSO for variable selection, we used multiple logistic regression to identify demographic and clinical predictors of BSO. Among 100 participants, 68 had undergone BSO at the time of interview. Of these 68, 35 were US-born (61% of all US-born participants) and 33 were not (77% of the non-US-born participants). Among Latinas with BRCA1/2 mutations, older age (p = 0.004), personal history of breast cancer (p = 0.003), higher income (p = 0.002), and not having a full-time job (p = 0.027) were identified as variables significantly associated with uptake of BSO. Results suggest a high rate of uptake of risk-reducing BSO among a sample of Latinas with BRCA1/2 mutations living in the US. We document factors associated with BSO uptake in a diverse sample of women. Relevant to genetic counseling, our findings identify possible targets for supporting Latinas' decision-making about BSO following receipt of a positive BRCA1/2 test. Copyright (c) 2020 National Society of Genetic Counselors.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *BRCA1 Protein/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *BRCA2 Protein/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Breast Neoplasms
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Hispanic Americans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Ovarian Neoplasms
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Breast Neoplasms/eh [Ethnology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Breast Neoplasms/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Breast Neoplasms/pc [Prevention & Control]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genetic Predisposition to Disease
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hispanic Americans/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mutation
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Ovarian Neoplasms/eh [Ethnology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Ovarian Neoplasms/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Ovarian Neoplasms/pc [Prevention & Control]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Ovariectomy
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Salpingo-oophorectomy
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution Washington Cancer Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Lynce, Filipa
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Schlam, Ilana
790 ## - Authors
All authors Ahn J, Campos C, Denduluri N, Dutil J, Friedman S, Geng X, Graves KD, Isaacs C, Lynce F, Nahleh Z, Peshkin BN, Ricker C, Rodriguez P, Schlam I
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1002/jgc4.1322">https://dx.doi.org/10.1002/jgc4.1322</a>
Public note https://dx.doi.org/10.1002/jgc4.1322
858 ## - ORCID
ORCID text Lynce, Filipa
-- Schlam, Ilana
Orcid <a href="https://orcid.org/0000-0001-6615-7076">https://orcid.org/0000-0001-6615-7076</a>
-- <a href="https://orcid.org/0000-0003-4996-0400">https://orcid.org/0000-0003-4996-0400</a>
Name https://orcid.org/0000-0001-6615-7076
-- https://orcid.org/0000-0003-4996-0400
-- https://orcid.org/0000-0001-6615-7076
-- https://orcid.org/0000-0003-4996-0400
858 ## - ORCID
ORCID text Lynce, Filipa
-- Schlam, Ilana
Orcid <a href="https://orcid.org/0000-0001-6615-7076">https://orcid.org/0000-0001-6615-7076</a>
-- <a href="https://orcid.org/0000-0003-4996-0400">https://orcid.org/0000-0003-4996-0400</a>
Name https://orcid.org/0000-0001-6615-7076
-- https://orcid.org/0000-0003-4996-0400
-- https://orcid.org/0000-0001-6615-7076
-- https://orcid.org/0000-0003-4996-0400
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
              12/29/2020   33010199 33010199 12/29/2020 12/29/2020 Journal Article

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