MARC details
000 -LEADER |
fixed length control field |
04360nam a22005657a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
210607s20212021 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
1059-7700 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1002/jgc4.1322 [doi] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
33010199 |
245 ## - TITLE STATEMENT |
Title |
BRCA1/2 mutations and risk-reducing bilateral salpingo-oophorectomy among Latinas: The UPTAKE study. |
251 ## - Source |
Source |
Journal of Genetic Counseling. 30(2):383-393, 2021 04. |
252 ## - Abbreviated Source |
Abbreviated source |
J Genet Couns. 30(2):383-393, 2021 04. |
252 ## - Abbreviated Source |
Former abbreviated source |
J Genet Couns. 30(2):383-393, 2021 Apr. |
253 ## - Journal Name |
Journal name |
Journal of genetic counseling |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2021 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2021 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
266 ## - Date added to catalog |
Date added to catalog |
2020-12-29 |
268 ## - Previous citation |
-- |
Journal of Genetic Counseling. 30(2):383-393, 2021 Apr. |
520 ## - SUMMARY, ETC. |
Abstract |
Bilateral salpingo-oophorectomy (BSO) is a risk management approach with strong evidence of mortality reduction for women with germline mutations in the tumor suppressor genes BRCA1 and BRCA2 (BRCA1/2). Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds who carry BRCA1/2 mutations. The objective of the UPTAKE study was to explore rates and predictors of risk-reducing BSO among Latinas affected and unaffected with breast cancer who had a deleterious BRCA1/2 mutation. We recruited 100 Latina women with deleterious BRCA1/2 mutations from community hospitals, academic health systems, community, and advocacy organizations. Women completed interviews in Spanish or English. We obtained copies of genetic test reports for participants who provided signed medical release. After performing threefold cross-validation LASSO for variable selection, we used multiple logistic regression to identify demographic and clinical predictors of BSO. Among 100 participants, 68 had undergone BSO at the time of interview. Of these 68, 35 were US-born (61% of all US-born participants) and 33 were not (77% of the non-US-born participants). Among Latinas with BRCA1/2 mutations, older age (p = 0.004), personal history of breast cancer (p = 0.003), higher income (p = 0.002), and not having a full-time job (p = 0.027) were identified as variables significantly associated with uptake of BSO. Results suggest a high rate of uptake of risk-reducing BSO among a sample of Latinas with BRCA1/2 mutations living in the US. We document factors associated with BSO uptake in a diverse sample of women. Relevant to genetic counseling, our findings identify possible targets for supporting Latinas' decision-making about BSO following receipt of a positive BRCA1/2 test. Copyright (c) 2020 National Society of Genetic Counselors. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*BRCA1 Protein/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*BRCA2 Protein/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Breast Neoplasms |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Hispanic Americans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Ovarian Neoplasms |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Breast Neoplasms/eh [Ethnology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Breast Neoplasms/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Breast Neoplasms/pc [Prevention & Control] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Female |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Genetic Predisposition to Disease |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Hispanic Americans/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Mutation |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Ovarian Neoplasms/eh [Ethnology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Ovarian Neoplasms/ge [Genetics] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Ovarian Neoplasms/pc [Prevention & Control] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Ovariectomy |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Salpingo-oophorectomy |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
Washington Cancer Institute |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Lynce, Filipa |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Schlam, Ilana |
790 ## - Authors |
All authors |
Ahn J, Campos C, Denduluri N, Dutil J, Friedman S, Geng X, Graves KD, Isaacs C, Lynce F, Nahleh Z, Peshkin BN, Ricker C, Rodriguez P, Schlam I |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1002/jgc4.1322">https://dx.doi.org/10.1002/jgc4.1322</a> |
Public note |
https://dx.doi.org/10.1002/jgc4.1322 |
858 ## - ORCID |
ORCID text |
Lynce, Filipa |
-- |
Schlam, Ilana |
Orcid |
<a href="https://orcid.org/0000-0001-6615-7076">https://orcid.org/0000-0001-6615-7076</a> |
-- |
<a href="https://orcid.org/0000-0003-4996-0400">https://orcid.org/0000-0003-4996-0400</a> |
Name |
https://orcid.org/0000-0001-6615-7076 |
-- |
https://orcid.org/0000-0003-4996-0400 |
-- |
https://orcid.org/0000-0001-6615-7076 |
-- |
https://orcid.org/0000-0003-4996-0400 |
858 ## - ORCID |
ORCID text |
Lynce, Filipa |
-- |
Schlam, Ilana |
Orcid |
<a href="https://orcid.org/0000-0001-6615-7076">https://orcid.org/0000-0001-6615-7076</a> |
-- |
<a href="https://orcid.org/0000-0003-4996-0400">https://orcid.org/0000-0003-4996-0400</a> |
Name |
https://orcid.org/0000-0001-6615-7076 |
-- |
https://orcid.org/0000-0003-4996-0400 |
-- |
https://orcid.org/0000-0001-6615-7076 |
-- |
https://orcid.org/0000-0003-4996-0400 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |