MARC details
000 -LEADER |
fixed length control field |
03164nam a22003857a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
221213s20222022 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
2376-0605 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1016/j.aace.2022.09.005 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
PMC9701813 [pmc] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
S2376-0605(22)00064-5 [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
36447833 |
245 ## - TITLE STATEMENT |
Title |
Localized Rhabdomyolysis Associated With Testosterone Enanthate for Gender-Affirming Hormonal Therapy. |
251 ## - Source |
Source |
Aace Clinical Case Reports. 8(6):264-266, 2022 Nov-Dec. |
252 ## - Abbreviated Source |
Abbreviated source |
AACE clin. case rep.. 8(6):264-266, 2022 Nov-Dec. |
253 ## - Journal Name |
Journal name |
AACE clinical case reports |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2022 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2023 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Publication date |
2022 Nov-Dec |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
epublish |
266 ## - Date added to catalog |
Date added to catalog |
2022-12-13 |
520 ## - SUMMARY, ETC. |
Abstract |
Background/Objective: Rhabdomyolysis is a condition characterized by the destruction of skeletal muscle tissue that leads to systemic complications. We present a case of gender-affirming intramuscular (IM) testosterone therapy precipitating localized deltoid rhabdomyolysis. |
520 ## - SUMMARY, ETC. |
Abstract |
Case Report: A 34-year-old transgender man presented to the emergency department with dark-colored urine and pain in the left deltoid muscle where he had been injecting IM testosterone. He was found to have significant elevation in the level of creatinine kinase that was consistent with rhabdomyolysis and managed with intravenous fluids. He received trial therapy with IM testosterone again in the contralateral deltoid twice with recurrent rhabdomyolysis. He eventually transitioned to subcutaneous testosterone to achieve his masculinization goals without adverse effects. |
520 ## - SUMMARY, ETC. |
Abstract |
Conclusion: This case report highlights the potential risk of rhabdomyolysis associated with IM testosterone administration in the deltoid region for gender-affirming care. Patients on IM testosterone should use the thigh or gluteal muscles rather than the deltoid. Copyright © 2022 AACE. Published by Elsevier Inc. |
520 ## - SUMMARY, ETC. |
Abstract |
Discussion: Localized anabolic steroid use has been associated with rhabdomyolysis. However, to the best of our knowledge, this is the first case report of rhabdomyolysis attributed to gender-affirming testosterone therapy. Our patient had been administering testosterone intramuscularly into larger muscles (thigh and gluteus) for many years without any issues, whereas recurrent focal rhabdomyolysis developed only in association with deltoid injections. We theorize that a relative increase in dose and volume of testosterone per gram of muscle after switching to the deltoid site precipitated rhabdomyolysis. Subcutaneous testosterone is an acceptable alternative to IM testosterone for patients desiring an injectable delivery route with minimal adverse effects. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Franklin Square Medical Center |
656 ## - INDEX TERM--OCCUPATION |
Department |
Endocrinology |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Case Reports |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Lizama-Hernandez, SergioW |
Institution Code |
MFSMC |
790 ## - Authors |
All authors |
Lizama-Hernandez S, Port AM, Reddy R |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1016/j.aace.2022.09.005">https://dx.doi.org/10.1016/j.aace.2022.09.005</a> |
Public note |
https://dx.doi.org/10.1016/j.aace.2022.09.005 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |