Localized Rhabdomyolysis Associated With Testosterone Enanthate for Gender-Affirming Hormonal Therapy. (Record no. 117)

MARC details
000 -LEADER
fixed length control field 03164nam a22003857a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 221213s20222022 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 2376-0605
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.aace.2022.09.005 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC9701813 [pmc]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S2376-0605(22)00064-5 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 36447833
245 ## - TITLE STATEMENT
Title Localized Rhabdomyolysis Associated With Testosterone Enanthate for Gender-Affirming Hormonal Therapy.
251 ## - Source
Source Aace Clinical Case Reports. 8(6):264-266, 2022 Nov-Dec.
252 ## - Abbreviated Source
Abbreviated source AACE clin. case rep.. 8(6):264-266, 2022 Nov-Dec.
253 ## - Journal Name
Journal name AACE clinical case reports
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2022
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2023
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2022 Nov-Dec
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status epublish
266 ## - Date added to catalog
Date added to catalog 2022-12-13
520 ## - SUMMARY, ETC.
Abstract Background/Objective: Rhabdomyolysis is a condition characterized by the destruction of skeletal muscle tissue that leads to systemic complications. We present a case of gender-affirming intramuscular (IM) testosterone therapy precipitating localized deltoid rhabdomyolysis.
520 ## - SUMMARY, ETC.
Abstract Case Report: A 34-year-old transgender man presented to the emergency department with dark-colored urine and pain in the left deltoid muscle where he had been injecting IM testosterone. He was found to have significant elevation in the level of creatinine kinase that was consistent with rhabdomyolysis and managed with intravenous fluids. He received trial therapy with IM testosterone again in the contralateral deltoid twice with recurrent rhabdomyolysis. He eventually transitioned to subcutaneous testosterone to achieve his masculinization goals without adverse effects.
520 ## - SUMMARY, ETC.
Abstract Conclusion: This case report highlights the potential risk of rhabdomyolysis associated with IM testosterone administration in the deltoid region for gender-affirming care. Patients on IM testosterone should use the thigh or gluteal muscles rather than the deltoid. Copyright © 2022 AACE. Published by Elsevier Inc.
520 ## - SUMMARY, ETC.
Abstract Discussion: Localized anabolic steroid use has been associated with rhabdomyolysis. However, to the best of our knowledge, this is the first case report of rhabdomyolysis attributed to gender-affirming testosterone therapy. Our patient had been administering testosterone intramuscularly into larger muscles (thigh and gluteus) for many years without any issues, whereas recurrent focal rhabdomyolysis developed only in association with deltoid injections. We theorize that a relative increase in dose and volume of testosterone per gram of muscle after switching to the deltoid site precipitated rhabdomyolysis. Subcutaneous testosterone is an acceptable alternative to IM testosterone for patients desiring an injectable delivery route with minimal adverse effects.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Franklin Square Medical Center
656 ## - INDEX TERM--OCCUPATION
Department Endocrinology
657 ## - INDEX TERM--FUNCTION
Medline publication type Case Reports
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Lizama-Hernandez, SergioW
Institution Code MFSMC
790 ## - Authors
All authors Lizama-Hernandez S, Port AM, Reddy R
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1016/j.aace.2022.09.005">https://dx.doi.org/10.1016/j.aace.2022.09.005</a>
Public note https://dx.doi.org/10.1016/j.aace.2022.09.005
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
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Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 12/13/2022   36447833 36447833 12/13/2022 12/13/2022 Journal Article

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