Epidemiologic Features of Recovery From SARS-CoV-2 Infection. (Record no. 14582)

MARC details
000 -LEADER
fixed length control field 04909nam a22005777a 4500
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fixed length control field 240807s20242024 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 2574-3805
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 2820087 [pii]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC11184459 [pmc]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 38884994
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Title Epidemiologic Features of Recovery From SARS-CoV-2 Infection.
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Source JAMA Network Open. 7(6):e2417440, 2024 Jun 03.
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Abbreviated source JAMA netw. open. 7(6):e2417440, 2024 Jun 03.
253 ## - Journal Name
Journal name JAMA network open
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Year 2024
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Manufacturer FY2024
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Publication date 2024 Jun 03
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status epublish
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Medline status MEDLINE
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Date added to catalog 2024-08-07
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Date Medline record created 2024/06/17 11:34
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Abstract Conclusions and Relevance: In this cohort study, more than 1 in 5 adults did not recover within 3 months of SARS-CoV-2 infection. Recovery within 3 months was less likely in women and those with preexisting cardiovascular disease and more likely in those with COVID-19 vaccination or infection during the Omicron variant wave.
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Abstract Design, Setting, and Participants: For this prospective cohort study, standardized ascertainment of SARS-CoV-2 infection was conducted starting in April 1, 2020, across 14 ongoing National Institutes of Health-funded cohorts that have enrolled and followed participants since 1971. This report includes data collected through February 28, 2023, on adults aged 18 years or older with self-reported SARS-CoV-2 infection.
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Abstract Exposure: Preinfection health conditions and lifestyle factors assessed before and during the pandemic via prepandemic examinations and pandemic-era questionnaires.
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Abstract Importance: Persistent symptoms and disability following SARS-CoV-2 infection, known as post-COVID-19 condition or "long COVID," are frequently reported and pose a substantial personal and societal burden.
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Abstract Main Outcomes and Measures: Probability of nonrecovery by 90 days and restricted mean recovery times were estimated using Kaplan-Meier curves, and Cox proportional hazards regression was performed to assess multivariable-adjusted associations with recovery by 90 days.
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Abstract Objective: To determine time to recovery following SARS-CoV-2 infection and identify factors associated with recovery by 90 days.
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Abstract Results: Of 4708 participants with self-reported SARS-CoV-2 infection (mean [SD] age, 61.3 [13.8] years; 2952 women [62.7%]), an estimated 22.5% (95% CI, 21.2%-23.7%) did not recover by 90 days post infection. Median (IQR) time to recovery was 20 (8-75) days. By 90 days post infection, there were significant differences in restricted mean recovery time according to sociodemographic, clinical, and lifestyle characteristics, particularly by acute infection severity (outpatient vs critical hospitalization, 32.9 days [95% CI, 31.9-33.9 days] vs 57.6 days [95% CI, 51.9-63.3 days]; log-rank P < .001). Recovery by 90 days post infection was associated with vaccination prior to infection (hazard ratio [HR], 1.30; 95% CI, 1.11-1.51) and infection during the sixth (Omicron variant) vs first wave (HR, 1.25; 95% CI, 1.06-1.49). These associations were mediated by reduced severity of acute infection (33.4% and 17.6%, respectively). Recovery was unfavorably associated with female sex (HR, 0.85; 95% CI, 0.79-0.92) and prepandemic clinical cardiovascular disease (HR, 0.84; 95% CI, 0.71-0.99). No significant multivariable-adjusted associations were observed for age, educational attainment, smoking history, obesity, diabetes, chronic kidney disease, asthma, chronic obstructive pulmonary disease, or elevated depressive symptoms. Results were similar for reinfections.
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Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *COVID-19
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Topical term or geographic name entry element *SARS-CoV-2
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Topical term or geographic name entry element Adult
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Topical term or geographic name entry element Aged
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Topical term or geographic name entry element COVID-19/ep [Epidemiology]
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Topical term or geographic name entry element Female
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Topical term or geographic name entry element Humans
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Topical term or geographic name entry element Male
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Topical term or geographic name entry element Middle Aged
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Topical term or geographic name entry element Pandemics
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Topical term or geographic name entry element Post-Acute COVID-19 Syndrome
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Topical term or geographic name entry element Prospective Studies
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Topical term or geographic name entry element United States/ep [Epidemiology]
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Indexing Automated
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Institution MedStar Health Research Institute
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Medline publication type Journal Article
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Local Authors Umans, Jason G
Institution Code MHRI
790 ## - Authors
All authors Oelsner EC, Sun Y, Balte PP, Allen NB, Andrews H, Carson A, Cole SA, Coresh J, Couper D, Cushman M, Daviglus M, Demmer RT, Elkind MSV, Gallo LC, Gutierrez JD, Howard VJ, Isasi CR, Judd SE, Kanaya AM, Kandula NR, Kaplan RC, Kinney GL, Kucharska-Newton AM, Lackland DT, Lee JS, Make BJ, Min YI, Murabito JM, Norwood AF, Ortega VE, Pettee Gabriel K, Psaty BM, Regan EA, Sotres-Alvarez D, Schwartz D, Shikany JM, Thyagarajan B, Tracy RP, Umans JG, Vasan RS, Wenzel SE, Woodruff PG, Xanthakis V, Zhang Y, Post WS
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DOI <a href="https://dx.doi.org/10.1001/jamanetworkopen.2024.17440">https://dx.doi.org/10.1001/jamanetworkopen.2024.17440</a>
Public note https://dx.doi.org/10.1001/jamanetworkopen.2024.17440
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article

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