Impact of Significant Hemoglobin Drop Without Bleeding in Patients Undergoing Transcatheter Aortic Valve Replacement. (Record no. 14589)

MARC details
000 -LEADER
fixed length control field 04845nam a22007577a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 240807s20242024 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 2047-9980
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 38818933
245 ## - TITLE STATEMENT
Title Impact of Significant Hemoglobin Drop Without Bleeding in Patients Undergoing Transcatheter Aortic Valve Replacement.
251 ## - Source
Source Journal of the American Heart Association. 13(11):e032291, 2024 Jun 04.
252 ## - Abbreviated Source
Abbreviated source J Am Heart Assoc. 13(11):e032291, 2024 Jun 04.
253 ## - Journal Name
Journal name Journal of the American Heart Association
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2024
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2024
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2024 Jun 04
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Medline status MEDLINE
266 ## - Date added to catalog
Date added to catalog 2024-08-07
266 ## - Date added to catalog
Date Medline record created 2024/05/31 07:13
520 ## - SUMMARY, ETC.
Abstract BACKGROUND: Hemoglobin (Hgb) drop without bleeding is common among patients undergoing transcatheter aortic valve replacement; however, the clinical implications of significant Hgb drop have not been fully evaluated.
520 ## - SUMMARY, ETC.
Abstract CONCLUSIONS: Hgb drop without bleeding is common among patients undergoing transcatheter aortic valve replacement and may represent a higher risk of periprocedural death. Blood transfusion increases short- and midterm mortality risk in patients with and without bleeding, supporting a restrictive transfusion strategy.
520 ## - SUMMARY, ETC.
Abstract METHODS AND RESULTS: Consecutive patients undergoing transcatheter aortic valve replacement at our institution from 2011 to 2021 were retrospectively reviewed. Three groups were assessed: no Hgb drop and no bleed (NoD-NoB [reference group]), Hgb drop with bleed, and Hgb drop and no bleed (D-NoB). Hgb drop was defined as >=3 g/dL decrease from pre- to post-transcatheter aortic valve replacement. Outcomes of interest were in-hospital death and 1-year all-cause mortality. A total of 1851 cases with complete Hgb data were included: NoD-NoB: n=1579 (85.3%); D-NoB: n=49 (2.6%); Hgb drop with bleed: n=223 (12.6%). Compared with NoD-NoB, the D-NoB group was older (81.1 versus 78.9 years of age) with higher preprocedure Hgb (12.9 versus 11.7 g/dL). In-hospital death rate was higher among patients with D-NoB versus NoD-NoB (4.5% versus 0.8%, P<0.001) and similar to Hgb drop with bleed (4.5% versus 4.1%, P=0.999). Predictors of in-hospital death were D-NoB (odds ratio [OR], 3.45 [95% CI, 1.32-8.69]) and transfusion (OR, 10.6 [95% CI, 4.25-28.2]). Landmark survival analysis found that D-NoB experienced 1-year mortality rate comparable to NoD-NoB, whereas Hgb drop with bleed had higher midterm mortality (hazard ratio [HR], 3.2 [95% CI, 1.83-5.73]), and transfusion continued to impact mortality (HR, 2.5 [95% CI, 1.79-3.63]).
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Aortic Valve Stenosis
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Hemoglobins
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Hospital Mortality
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Transcatheter Aortic Valve Replacement
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged, 80 and over
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Stenosis/mo [Mortality]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aortic Valve Stenosis/su [Surgery]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hemoglobins/an [Analysis]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hemoglobins/me [Metabolism]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Retrospective Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Assessment/mt [Methods]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Factors
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Transcatheter Aortic Valve Replacement/ae [Adverse Effects]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Transcatheter Aortic Valve Replacement/mo [Mortality]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Treatment Outcome
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Indexing Curated
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Heart & Vascular Institute
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Washington Hospital Center
656 ## - INDEX TERM--OCCUPATION
Department Advanced Cardiac Catheterization Research Fellowship
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Ben-Dor, Itsik
Institution Code MHVI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Cellamare, Matteo
Institution Code MHVI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Garcia-Garcia, Hector M
Institution Code MHVI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Merdler, Ilan
Institution Code MHVI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Reddy, Pavan
Institution Code MWHC
Program Advanced Cardiac Catheterization Research Fellowship
Degree MD
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Rogers, Toby
Institution Code MHVI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Satler, Lowell F
Institution Code MHVI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Waksman, Ron
Institution Code MHVI
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Zhang, Cheng
Institution Code MHVI
790 ## - Authors
All authors Reddy P, Merdler I, Zhang C, Cellamare M, Ben-Dor I, Satler LF, Rogers T, Garcia-Garcia HM, Waksman R
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1161/JAHA.123.032291">https://dx.doi.org/10.1161/JAHA.123.032291</a>
Public note https://dx.doi.org/10.1161/JAHA.123.032291
858 ## - ORCID
ORCID text Garcia-Garcia, Hector M
Orcid <a href="https://orcid.org/0000-0001-5100-0471">https://orcid.org/0000-0001-5100-0471</a>
Name https://orcid.org/0000-0001-5100-0471
858 ## - ORCID
ORCID text Reddy, Pavan
Orcid <a href="https://orcid.org/0000-0001-8913-7430">https://orcid.org/0000-0001-8913-7430</a>
Name https://orcid.org/0000-0001-8913-7430
858 ## - ORCID
ORCID text Rogers, Toby
Orcid <a href="https://orcid.org/0000-0002-6043-3137">https://orcid.org/0000-0002-6043-3137</a>
Name https://orcid.org/0000-0002-6043-3137
858 ## - ORCID
ORCID text Satler, Lowell F
Orcid <a href="https://orcid.org/0000-0001-6446-2683">https://orcid.org/0000-0001-6446-2683</a>
Name https://orcid.org/0000-0001-6446-2683
858 ## - ORCID
ORCID text Waksman, Ron
Orcid <a href="https://orcid.org/0000-0002-4063-9226">https://orcid.org/0000-0002-4063-9226</a>
Name https://orcid.org/0000-0002-4063-9226
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article

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