MARC details
| 000 -LEADER |
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| fixed length control field |
03193nam a22003857a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210607s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0167-6806 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s10549-020-05849-2 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s10549-020-05849-2 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
32776290 |
| 245 ## - TITLE STATEMENT |
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| Title |
Actionable co-alterations in breast tumors with pathogenic mutations in the homologous recombination DNA damage repair pathway. |
| 251 ## - Source |
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| Source |
Breast Cancer Research & Treatment. 184(2):265-275, 2020 Nov. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Breast Cancer Res Treat. 184(2):265-275, 2020 Nov. |
| 253 ## - Journal Name |
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| Journal name |
Breast cancer research and treatment |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-09-02 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: HR-MT was common across breast cancer subtypes and co-occurred more frequently with markers of response to immunotherapy (MSI-H/dMMR, TMB) compared to HR-WT tumors. Mutations were identified in both HR-MT and HR-WT tumors that suggest other targets for treatment. Clinical trials combining HRD-targeted agents and immunotherapy are underway and could be enriched through comprehensive molecular profiling. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: Comprehensive molecular profiles of 4647 breast tumors performed at Caris Life Sciences using 592-gene NGS were reviewed to identify somatic pathogenic mutations in HR genes ARID1A, ATM, ATRX, BAP1, BARD1, BLM, BRCA1/2, BRIP1, CHEK1/2, FANCA/C/D2/E/F/G/L, KMT2D, MRE11, NBN, PALB2, RAD50/51/51B, and WRN, as well as 41 markers that may be associated with treatment response to targeted anticancer therapies. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
PURPOSE: Homologous recombination (HR)-deficient breast tumors may have genomic alterations that predict response to treatment with PARP inhibitors and other targeted therapies. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: 17.9% of breast tumors had HR mutations (HR-MT, 831/4647) [ER/PR+ , HER2- 18.3%, n = 2183; TNBC 18.2%, n = 1568; ER/PR+ , HER2+ 15.6%, n = 237; ER/PR-, HER2+ 12.9%, n = 217; unknown n = 442]. Mean TMB was higher for HR-MT tumors across subtypes (9.2 mut/Mb vs 7.6 h-wild type (HR-WT), p <= 0.0001) and independent of microsatellite status. MSI-H/dMMR was more frequent among HR-MT tumors (2.1% HR-MT vs 0.2% HR-WT, p <= 0.0001), as was tumor PD-L1 overexpression (13.2% HR-MT vs 11.0% HR-WT, p = 0.08). Additional co-alterations were similar between HR-MT and HR-WT, with the exception of PIK3CA (30.3% HR-WT vs 26.4% HR-MT, p = 0.024) and AKT1 (3.7% HR-WT vs 2.1% HR-MT, p = 0.021). AR overexpression and PIK3CA mutations were more common among ER/PR+ tumors. ERBB2 mutations were seen in both HER2+ and HER2- tumors. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
Washington Cancer Institute |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Associate Dean for Research Development |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
MedStar Health |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Lynce, Filipa |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Swain, Sandra M |
| 790 ## - Authors |
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| All authors |
Elliott A, Heeke AL, Isaacs C, Korn WM, Lynce F, Pohlmann PR, Schwartzberg LS, Swain SM, Tan AR, Vidal G, Xiu J |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1007/s10549-020-05849-2">https://dx.doi.org/10.1007/s10549-020-05849-2</a> |
| Public note |
https://dx.doi.org/10.1007/s10549-020-05849-2 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
