Can Clinical Response Predict Pathologic Response Following Neoadjuvant Chemoradiation for Esophageal Cancer?. (Record no. 571)

MARC details
000 -LEADER
fixed length control field 03234nam a22004337a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 220511s20222022 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1091-255X
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/s11605-022-05315-y [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1007/s11605-022-05315-y [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 35414141
245 ## - TITLE STATEMENT
Title Can Clinical Response Predict Pathologic Response Following Neoadjuvant Chemoradiation for Esophageal Cancer?.
251 ## - Source
Source Journal of Gastrointestinal Surgery. 2022 Apr 12
252 ## - Abbreviated Source
Abbreviated source J Gastrointest Surg. 2022 Apr 12
253 ## - Journal Name
Journal name Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2022
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2022
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Publication date 2022 Apr 12
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status aheadofprint
266 ## - Date added to catalog
Date added to catalog 2022-05-11
520 ## - SUMMARY, ETC.
Abstract CONCLUSIONS: Current restaging tools cannot reliably predict ypCR after nCRT. While multimodal restaging appears to be a more accurate predictor of ypCR than any testing modality alone, patients cannot reliably be advised to avoid an esophagectomy on the assumption that ycCR predicts ypCR at this time. Copyright © 2022. The Society for Surgery of the Alimentary Tract.
520 ## - SUMMARY, ETC.
Abstract METHODS: Patients undergoing esophagectomy following nCRT at three major institutions between 2005 and 2018 were reviewed. Restaging, including PET/CT, endoscopy with biopsy, and esophageal ultrasound (EUS), was performed to determine ycCR.
520 ## - SUMMARY, ETC.
Abstract OBJECTIVES: Approximately 20-40% of patients with locally advanced esophageal cancer will achieve a pathologic complete response (ypCR) following neoadjuvant chemoradiotherapy (nCRT). Predicting ypCR based on a clinical complete response (ycCR) has been a challenge. This study assessed the correlation between ycCR and ypCR, as determined from esophagectomy specimens.
520 ## - SUMMARY, ETC.
Abstract RESULTS: Six hundred sixty patients were included, with 93.3% with esophageal adenocarcinoma histology. Six hundred fifty-eight of these patients underwent PET, 304 EUS, and 584 underwent a biopsy. Following nCRT, 148 (22.4%) were found to have a ypCR. Only 12/32 (37.5%) determined to have a ycCR were found to have a ypCR, while 136/628 (21.6%) with a non-ycCR were found to have a ypCR (p 0.075). Individual modality PPV was 28% for PET, 54% for EUS, and 26% for biopsy. When PET was combined with EUS, 168 reports were concordant and the PPV of ypCR was 50%, though the number of patients was low (1/2). With all 3 re-staging modalities combined, the PPV and NPV both rose to 100%.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Washington Hospital Center
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Department MedStar General Surgery Residency
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Department MedStar Georgetown University Hospital/MedStar Washington Hospital Center
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Department Surgery/Thoracic Surgery
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Desale, Sameer
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Holliday, Tyler
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Khaitan, Puja G
790 ## - Authors
All authors Bayley EM, Carroll A, Desale S, Hofstetter WL, Holliday T, Khaitan PG, Watson TJ, Zhou N
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1007/s11605-022-05315-y">https://dx.doi.org/10.1007/s11605-022-05315-y</a>
Public note https://dx.doi.org/10.1007/s11605-022-05315-y
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 05/11/2022   35414141 35414141 05/11/2022 05/11/2022 Journal Article

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