Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population. (Record no. 6220)
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fixed length control field | 02904nam a22003137a 4500 |
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fixed length control field | 210310s20212021 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
International Standard Serial Number | 2509-2723 |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1007/s11357-020-00321-x [doi] |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1007/s11357-020-00321-x [pii] |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
PMID | 33598853 |
245 ## - TITLE STATEMENT | |
Title | Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population. |
251 ## - Source | |
Source | GeroScience. 2021 Feb 18 |
252 ## - Abbreviated Source | |
Abbreviated source | Geroscience. 2021 Feb 18 |
253 ## - Journal Name | |
Journal name | GeroScience |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Year | 2021 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Manufacturer | FY2021 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
Publication status | aheadofprint |
266 ## - Date added to catalog | |
Date added to catalog | 2021-03-10 |
520 ## - SUMMARY, ETC. | |
Abstract | Although mechanical energy transfer between the heart and arterial system, referred to as arterial-ventricular (AV) coupling, is an important determinant of cardiovascular performance, how AV coupling changes over time within and among individuals as they age has not been fully explored. We studied 129 participants (baseline age 21-96) of the Baltimore Longitudinal Study of Aging, free of clinical CVD. Participants underwent repeated multigated cardiac blood pool scans to estimate left ventricular (LV) volumes (SV, EDV, and ESV). Total systemic vascular resistance (TSVR), total arterial compliance (TAC), effective arterial elastance (Ea), and end-systolic LV elastance (Elv) were calculated using LV volumes and brachial BP measurements; calculated Ea/Elv was the measure of AV coupling. Linear mixed-effects models were used to estimate person-specific rates of change (Change) for each variable. The rate at which Ea increased over time was faster than the rate at which Elv increased, resulting in AV uncoupling (increased Ea/Elv) over time that was significantly greater in women than in men. Loss of arterial compliance was the main determinant of (Ea/Elv)Change, which was negatively associated with changes in SV and EDV but positively with changes in ESV. Progressive AV uncoupling occurred with aging and was more pronounced in women than men. While Ea change did not differ by sex, Elv increased at a slower rate in women than in men. AV uncoupling was inversely associated with EDV and SV rates of change and a directly associated with an increase in ESV rate of change. Additional studies are needed to explore the functional consequences of AV uncoupling in healthy individuals with respect to the emergence of age-associated clinical cardiovascular diseases, such as heart failure with preserved ejection fraction. |
546 ## - LANGUAGE NOTE | |
Language note | English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Heart & Vascular Institute |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Najjar, Samer S |
790 ## - Authors | |
All authors | AlGhatrif M, Becker LC, Chantler PD, Ferrucci L, Gerstenblith G, Lakatta EG, Morrell CH, Najjar SS |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
DOI | <a href="https://dx.doi.org/10.1007/s11357-020-00321-x">https://dx.doi.org/10.1007/s11357-020-00321-x</a> |
Public note | https://dx.doi.org/10.1007/s11357-020-00321-x |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Journal Article |
Item type description | Article |
Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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MedStar Authors Catalog | MedStar Authors Catalog | 03/10/2021 | 33598853 | 33598853 | 03/10/2021 | 03/10/2021 | Journal Article |