A Case Report and Literature Review on Argatroban Refractory Heparin-Induced Thrombocytopenia. (Record no. 78)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03087nam a22003617a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221213s20222022 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2000-9666 |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.55729/2000-9666.1102 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | jchim-12-05-102 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | PMC9529653 [pmc] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 36262487 |
| 245 ## - TITLE STATEMENT | |
| Title | A Case Report and Literature Review on Argatroban Refractory Heparin-Induced Thrombocytopenia. |
| 251 ## - Source | |
| Source | Journal of Community Hospital Internal Medicine Perspectives. 12(5):102-105, 2022. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | J Community Hosp Intern Med Perspect. 12(5):102-105, 2022. |
| 253 ## - Journal Name | |
| Journal name | Journal of community hospital internal medicine perspectives |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2023 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | epublish |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2022-12-13 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | Heparin-induced thrombocytopenia (HIT) is characterized by low platelets and thrombosis after exposure to Heparin products. It is classically characterized by a rapid and significant drop in platelets and life-threatening thrombosis. Thrombosis can occur up to 50% of the cases if left untreated. It requires immediate discontinuation of all heparin products and switching to a non-heparin anticoagulant to prevent further thrombosis. Here we present a case of a 56-year-old male who presented to the Emergency Department with sudden onset of severe left leg pain. Duplex study showed arterial thrombosis in the common iliac and distal iliac arteries. He received TPA at once and underwent thrombectomy while his platelet continued to drop. He used Low Molecular Weight Heparin (enoxaparin) for bridging after his tonsil surgery a week prior to this hospital admission. His HIT assay was found to be positive and despite the Argatroban therapy his clinical condition continued to worsen while his platelet count continued to drop. Given the refractory nature of the thrombosis and thrombocytopenia; Intravenous immunoglobulin (IVIG) therapy was introduced. The patient showed a great response and his platelet count improved to 150,000/mu. He was discharged on warfarin with a closer follow-up. Few case reports have described the treatment of such refractory cases using intravenous immunoglobulin (IVIG), resulting in stabilized platelet counts, reduced platelet activation, and reduced thrombotic complications, the exact mechanism of which is unknown. It is thought that IVIG inhibits platelet activation by binding as platelet receptors, which would otherwise bind with heparin-platelet factor 4 complexes and HIT antibodies. Copyright © 2022 Greater Baltimore Medical Center. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Union Memorial Hospital |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Internal Medicine Residency |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Case Reports |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Deen, Imad U |
| Institution Code | MUMH |
| Program | Internal Medicine Residency |
| Degree | MBBS |
| Resident year | Resident PGY 3 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Jha, Swati A |
| Institution Code | MUMH |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Mustafa, Sadaf |
| Institution Code | MUMH |
| 790 ## - Authors | |
| All authors | Deen IU, Jha SA, Mustafa S |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.55729/2000-9666.1102">https://dx.doi.org/10.55729/2000-9666.1102</a> |
| Public note | https://dx.doi.org/10.55729/2000-9666.1102 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 12/13/2022 | 36262487 | 36262487 | 12/13/2022 | 12/13/2022 | Journal Article |