Differentiated thyroid cancer and Hashimoto thyroiditis: Utility of the Afirma gene expression classifier. (Record no. 8609)

000 -LEADER
fixed length control field 03649nam a22007457a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 200709s20202020 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0022-4790
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1002/jso.25875 [doi]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number 32115718
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Felger, Erin A
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Lee, Wen
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Papoian, Vardan
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Rosen, Jennifer E
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Wartofsky, Leonard
190 ## -
-- Felger EA
190 ## -
-- Lee W
190 ## -
-- Papoian V
190 ## -
-- Rosen JE
190 ## -
-- Wartofsky L
245 ## - TITLE STATEMENT
Title Differentiated thyroid cancer and Hashimoto thyroiditis: Utility of the Afirma gene expression classifier.
251 ## -
-- Journal of Surgical Oncology. 121(7):1053-1057, 2020 Jun.
251 ## -
-- Journal of Surgical Oncology. 121(7):1053-1057, 2020 Jun.
252 ## -
-- J Surg Oncol. 121(7):1053-1057, 2020 Jun.
252 ## -
-- J Surg Oncol. 121(7):1053-1057, 2020 Jun.
253 ## -
-- Journal of surgical oncology
260 ## - PUBLICATION, DISTRIBUTION, ETC.
-- 2020
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2020
260 ## - PUBLICATION, DISTRIBUTION, ETC.
-- ppublish
269 ## -
-- FY2020
520 ## - SUMMARY, ETC.
Summary, etc. BACKGROUND AND OBJECTIVES: The Afirma gene expression classifier (AGEC) has not been tested or validated in a high-risk group, such as patients with Hashimoto's thyroiditis (HT). We hypothesized that AGEC would perform worse in patients with HT.
520 ## - SUMMARY, ETC.
Summary, etc. CONCLUSIONS: We observed a lower NPV for AGEC to rule out thyroid cancer in patients with HT, which reduces the utility of the test for this population. Copyright (c) 2020 Wiley Periodicals, Inc.
520 ## - SUMMARY, ETC.
Summary, etc. METHODS: A retrospective review of patient charts in a single academic institution who underwent thyroidectomy between 2012 and 2017 was conducted. Patients with HT who underwent AGEC were identified to calculate sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
520 ## - SUMMARY, ETC.
Summary, etc. RESULTS: We identified 69 patients with HT and atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) on cytology who underwent AGEC analysis. The mean age of AGEC cohort was 50 years (range, 26-77 years) with 90% female. The median nodule size was 1.9 cm (interquartile range [IQR], 1.2-2.7 cm). Of the 69 patients, 62 showed suspicious AGEC of which 26 showed TC on surgical pathology. Of the seven benign AGEC, two showed TC on surgical pathology. The sensitivity, specificity, PPV, and NPV were 93%, 12%, 42%, and 71%, respectively. Of the entire AGEC cohort, 17 (43%) showed multicentric disease.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adult
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thyroidectomy
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thyroid Nodule/su [Surgery]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thyroid Nodule/pa [Pathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thyroid Nodule/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thyroid Neoplasms/su [Surgery]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thyroid Neoplasms/pa [Pathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Thyroid Neoplasms/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Retrospective Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Reproducibility of Results
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hashimoto Disease/su [Surgery]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hashimoto Disease/pa [Pathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Hashimoto Disease/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Gene Expression Profiling/mt [Methods]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cohort Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name MedStar Washington Hospital Center
656 ## - INDEX TERM--OCCUPATION
Occupation Medicine/Endocrinology
656 ## - INDEX TERM--OCCUPATION
Occupation Pathology
656 ## - INDEX TERM--OCCUPATION
Occupation Surgery/Endocrine Surgery
656 ## - INDEX TERM--OCCUPATION
Occupation Surgery/General Surgery
657 ## - INDEX TERM--FUNCTION
Function Journal Article
857 ## -
-- https://dx.doi.org/10.1002/jso.25875
858 ## -
-- Papoian, Vardan
-- http://orcid.org/0000-0002-2572-1483
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection code Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 2020-07-09 32115718 2020-07-09 2020-07-09 Journal Article

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