Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study. (Record no. 8748)

000 -LEADER
fixed length control field 04584nam a22010457a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 200826s20202020 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0804-4643
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1530/EJE-19-0506 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code EJE-19-0506.R4 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number 32567556
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Ho, An Thi Nhat
190 ## -
-- Antke C
190 ## -
-- Arlt W
190 ## -
-- Beuschlein F
190 ## -
-- Casanovas O
190 ## -
-- Chortis V
190 ## -
-- Fassnacht M
190 ## -
-- Gattermann N
190 ## -
-- Germing U
190 ## -
-- Gimm O
190 ## -
-- Haas R
190 ## -
-- Haase M
190 ## -
-- Habra M
190 ## -
-- Ho ATN
190 ## -
-- Kanji A
190 ## -
-- Kondakci M
190 ## -
-- Laurent C
190 ## -
-- Limvorapitak W
190 ## -
-- Majidi F
190 ## -
-- Martino S
190 ## -
-- Petit JM
190 ## -
-- Ronchi CL
190 ## -
-- Rudelius M
190 ## -
-- Salvatori R
190 ## -
-- Schott M
190 ## -
-- Spyroglou A
190 ## -
-- Villa D
190 ## -
-- Wahlin BE
245 ## - TITLE STATEMENT
Title Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study.
251 ## -
-- European Journal of Endocrinology. 2020 Jun 01
251 ## -
-- European Journal of Endocrinology. 183(4):453-462, 2020 Oct.
252 ## -
-- EUR. J. ENDOCRINOL.. 2020 Jun 01
252 ## -
-- EUR. J. ENDOCRINOL.. 183(4):453-462, 2020 Oct.
253 ## -
-- European journal of endocrinology
260 ## - PUBLICATION, DISTRIBUTION, ETC.
-- 2020
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2020
260 ## - PUBLICATION, DISTRIBUTION, ETC.
-- ppublish
260 ## - PUBLICATION, DISTRIBUTION, ETC.
-- aheadofprint
269 ## -
-- FY2021
269 ## -
-- FY2020
520 ## - SUMMARY, ETC.
Summary, etc. CONCLUSION: We found unexpected heterogeneity in the clinical spectrum of PAL. Further studies are needed to clarify whether clinical distinction between iPAL and PAL+ is corroborated by differences in molecular biology.
520 ## - SUMMARY, ETC.
Summary, etc. METHODS: 97 patients from 14 centers in Europe, Canada and the United States were included in this retrospective analysis between 1994 and 2017.
520 ## - SUMMARY, ETC.
Summary, etc. PURPOSE: We sought to refine the clinical picture of primary adrenal lymphoma (PAL), a rare lymphoid malignancy with predominant adrenal manifestation and risk of adrenal insufficiency.
520 ## - SUMMARY, ETC.
Summary, etc. RESULTS: Of 81 patients with imaging data, 19 (23%) had isolated adrenal involvement (iPAL), while 62 (77%) had additional extra-adrenal involvement (PAL+). Among patients who had both CT and PET scans, 18FDG-PET revealed extra-adrenal involvement not detected by CT scan in 9/18 cases (50%). The most common clinical manifestations were B symptoms (55%), fatigue (45%), and abdominal pain (35%). Endocrinological assessment was often inadequate. With a median follow-up of 41.6 months, 3-year progression-free (PFS) and overall (OS) survival rates in the entire cohort were 35.5% and 39.4%, respectively. The hazard ratios of iPAL for PFS and OS were 40.1 (95% CI: 2.63-613.7, p=0.008) and 2.69 (95% CI: 0.61-11.89, p=0.191), respectively. PFS was much shorter in iPAL versus PAL+ (median 4 months vs. not reached, p=0.006), and OS also appeared to be shorter (median 16 months vs. not reached), but the difference did not reach statistical significance (p=0.16). Isolated PAL was more frequent in females (OR=3.81; P=0.01) and less frequently associated with B symptoms (OR= 0.159; p=0.004).
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adrenal Gland Neoplasms/co [Complications]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element United States/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Tomography, X-Ray Computed
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Factors
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Retrospective Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Positron-Emission Tomography
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Phenotype
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Multimodal Imaging
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Lymphoma/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Lymphoma/di [Diagnosis]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Lymphoma/co [Complications]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Fluorodeoxyglucose F18/pk [Pharmacokinetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Europe/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Diagnosis, Differential
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cohort Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Canada/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged, 80 and over
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adult
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adrenal Insufficiency/et [Etiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adrenal Insufficiency/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Adrenal Insufficiency/di [Diagnosis]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Adrenal Gland Neoplasms/ep [Epidemiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Adrenal Gland Neoplasms/di [Diagnosis]
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name MedStar Union Memorial Hospital
656 ## - INDEX TERM--OCCUPATION
Occupation Medicine
657 ## - INDEX TERM--FUNCTION
Function Journal Article
857 ## -
-- https://dx.doi.org/10.1530/EJE-19-0506
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection code Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 2020-08-26 32567556 2020-08-26 2020-08-26 Journal Article

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